Multivalent, Saccharide-Functionalized Gold Nanoparticles as Fully Synthetic Analogs of Type A Neisseria meningitidis Antigens

被引：40

作者：

Manea, Flavio ^{[1
]}

Bindoli, Cristiano ^{[1
]}

Fallarini, Silvia ^{[2
]}

Lombardi, Grazia ^{[2
]}

Polito, Laura ^{[3
,4
]}

Lay, Luigi ^{[3
,4
]}

Bonomi, Renato ^{[1
]}

Mancin, Fabrizio ^{[1
]}

Scrimin, Paolo ^{[1
]}

机构：

[1] Univ Padua, Dept Chem Sci, I-35131 Padua, Italy

[2] Univ E Piedmont, Dept SCAFF, I-28100 Novara, Italy

[3] Univ Milan, Dept Organ & Ind Chem, I-20133 Milan, Italy

[4] Univ Milan, CISI, I-20133 Milan, Italy

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 22期

关键词：

D O I：

10.1002/adma.200800737

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antigen analogs of polyclonal antibodies specific for type A Neisseria mengitidis are prepared by covering gold clusters (2-5 nm in size) with a monolayer of saccharides that have the structure of the repeating unit of the capsular polysaccharide of this bacterium. These systems may find use as synthetic antigens for desired nanoscale catalysts.

引用

收藏

页码：4348 / 4352

页数：5

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