The Role of Delayed 18F-FDG PET Imaging in the Follow-up of Patients with Alveolar Echinococcosis
被引:71
作者:
Caoduro, Cecile
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Univ Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Univ Hosp, Besancon, FranceUniv Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Caoduro, Cecile
[1
,2
]
Porot, Clemence
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机构:
Univ Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Univ Hosp, Besancon, FranceUniv Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Porot, Clemence
[1
,2
]
Vuitton, Dominique A.
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机构:
WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, FranceUniv Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Vuitton, Dominique A.
[3
]
Bresson-Hadni, Solange
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机构:
WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Dept Hepatol, Besancon, France
Univ Franche Comte, UMR CNRS Chronoenvironm 6249, F-25030 Besancon, FranceUniv Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Bresson-Hadni, Solange
[3
,4
,5
]
Grenouillet, Frederic
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机构:
WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Franche Comte, UMR CNRS Chronoenvironm 6249, F-25030 Besancon, France
Univ Hosp, Dept Mycol & Parasitol, Besancon, FranceUniv Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Grenouillet, Frederic
[3
,5
,6
]
Richou, Carine
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机构:
WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Dept Hepatol, Besancon, FranceUniv Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Richou, Carine
[3
,4
]
Boulahdour, Hatem
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Univ Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Univ Hosp, Besancon, FranceUniv Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Boulahdour, Hatem
[1
,2
]
Blagosklonov, Oleg
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Univ Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Univ Hosp, Besancon, France
WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, FranceUniv Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
Blagosklonov, Oleg
[1
,2
,3
]
机构:
[1] Univ Franche Comte, EA Nanomed Lab 4662, Dept Biophys & Nucl Med, F-25030 Besancon, France
[2] Univ Hosp, Besancon, France
[3] WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
[4] Univ Hosp, Dept Hepatol, Besancon, France
[5] Univ Franche Comte, UMR CNRS Chronoenvironm 6249, F-25030 Besancon, France
[6] Univ Hosp, Dept Mycol & Parasitol, Besancon, France
F-18-FDG PET has already proved its usefulness in the follow-up of patients with alveolar echinococcosis (AE) and has been proposed as a surrogate marker for therapeutic decisions on structured treatment interruption by benzimidazoles. However, standard PET acquisition (1 h after F-18-FDG injection) lacks sensitivity, and the parasite may stay viable even if F-18-FDG perilesional uptake has disappeared. The aim of our study was to evaluate the usefulness of delayed F-18-FDG PET in the management of AE patients. Methods: During a 6-y period, 120 PET scans using F-18-FDG were obtained for 70 AE patients treated by benzimidazoles, without selection. All patients underwent whole-body imaging on a PET/CT device 1 h after F-18-FDG injection (4 MBq/kg), as well as an acquisition focused on the liver 3 h after the injection. We also analyzed the results of serologic tests. Results: Of the 57 scans considered negative at the standard acquisition, 13 (22.8%) became clearly positive at the delayed acquisition, and 6 (10.5%) became indeterminate at the delayed acquisition. Furthermore, 20 of 22 scans interpreted as indeterminate at the standard acquisition were considered positive because of clear perilesional F-18-FDG uptake at the delayed acquisition. Thus, delayed acquisition changed the interpretation in 32.5% of cases. Moreover, of 44 patients treated by benzimidazoles and followed for more than 2 y by regular F-18-FDG PET scans and specific AE serology, 11 (25%) presented pathologic F-18-FDG uptake at the delayed acquisition but not at the standard one. In these patients, the treatment was continued despite negative results on standard F-18-FDG PET and negative serologic findings. On the other hand, in 7 patients with negative delayed F-18-FDG PET and negative serology, the treatment was safely interrupted with no evidence of disease recurrence during 8-37 mo (mean, 23 mo). Conclusion: Our study clearly demonstrated that delayed F-18-FDG PET greatly facilitated the differentiation between active and inactive liver lesions in AE patients. Also, our results strongly suggested that the combination of delayed F-18-FDG PET and specific serology would prevent most of the recurrences observed after premature interruption of the treatment based only on standard F-18-FDG PET.
机构:
Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Liver Dis Unit, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Crouzet, J.
;
Grenouillet, F.
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Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Dept Parasitol Mycol, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Grenouillet, F.
;
Delabrousse, E.
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Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Dept Radiol, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Delabrousse, E.
;
Blagosklonov, O.
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Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Dept Nucl Med, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Blagosklonov, O.
;
Thevenot, T.
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Univ Hosp, Liver Dis Unit, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Thevenot, T.
;
Di Martino, V.
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Univ Hosp, Liver Dis Unit, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Di Martino, V.
;
Piarroux, R.
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机构:
Univ Hosp, Dept Parasitol Mycol, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Piarroux, R.
;
Mantion, G. A.
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Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Mantion, G. A.
;
Bresson-Hadni, S.
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Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
机构:
Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Liver Dis Unit, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Crouzet, J.
;
Grenouillet, F.
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h-index: 0
机构:
Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Dept Parasitol Mycol, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Grenouillet, F.
;
Delabrousse, E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Dept Radiol, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Delabrousse, E.
;
Blagosklonov, O.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Univ Hosp, Dept Nucl Med, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Blagosklonov, O.
;
Thevenot, T.
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h-index: 0
机构:
Univ Hosp, Liver Dis Unit, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Thevenot, T.
;
Di Martino, V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Liver Dis Unit, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Di Martino, V.
;
Piarroux, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Dept Parasitol Mycol, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Piarroux, R.
;
Mantion, G. A.
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h-index: 0
机构:
Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France
Mantion, G. A.
;
Bresson-Hadni, S.
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h-index: 0
机构:
Univ Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, FranceUniv Hosp, WHO Collaborating Ctr Prevent & Treatment Human E, Besancon, France