共 64 条
Distinct contributions of MSL complex subunits to the transcriptional enhancement responsible for dosage compensation in Drosophila
被引:15
作者:

Dunlap, David
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA

Yokoyama, Ruth
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA

Ling, Huiping
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA

Sun, He-Ying
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA

McGill, Kerry
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA

Cugusi, Simona
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA

Lucchesi, John C.
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA
机构:
[1] Emory Univ, Dept Cell Biol, Atlanta, GA 30322 USA
[2] Emory Univ, Dept Biol, Atlanta, GA 30322 USA
基金:
美国国家卫生研究院;
关键词:
ORDER CHROMATIN-STRUCTURE;
NUCLEOSOME CORE PARTICLE;
REMODELING ATPASE ISWI;
H4 TAIL ACETYLATIONS;
X-CHROMOSOME;
IN-VIVO;
HISTONE ACETYLATION;
H4-K16;
ACETYLATION;
ANALYSIS REVEALS;
GENE-EXPRESSION;
D O I:
10.1093/nar/gks890
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The regulatory mechanism of dosage compensation is the paramount example of epigenetic regulation at the chromosomal level. In Drosophila, this mechanism, designed to compensate for the difference in the dosage of X-linked genes between the sexes, depends on the MSL complex that enhances the transcription of the single dose of these genes in males. We have investigated the function of various subunits of the complex in mediating dosage compensation. Our results confirm that the highly enriched specific acetylation of histone H4 at lysine 16 of compensated genes by the histone acetyl transferase subunit MOF induces a more disorganized state of their chromatin. We have determined that the association of the MSL complex reduces the level of negative supercoiling of the deoxyribonucleic acid of compensated genes, and we have defined the role that the other subunits of the complex play in this topological modification. Lastly, we have analyzed the potential contribution of ISWI-containing remodeling complexes to the architecture of compensated chromatin, and we suggest a role for this remodeling factor in dosage compensation.
引用
收藏
页码:11281 / 11291
页数:11
相关论文
共 64 条
[1]
High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome
[J].
Alekseyenko, AA
;
Larschan, E
;
Lai, WR
;
Park, PJ
;
Kuroda, MI
.
GENES & DEVELOPMENT,
2006, 20 (07)
:848-857

Alekseyenko, AA
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Howard Hughes Med Inst, 75 Francis St, Boston, MA 02115 USA

Larschan, E
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Howard Hughes Med Inst, 75 Francis St, Boston, MA 02115 USA

Lai, WR
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Howard Hughes Med Inst, 75 Francis St, Boston, MA 02115 USA

Park, PJ
论文数: 0 引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Howard Hughes Med Inst, 75 Francis St, Boston, MA 02115 USA Brigham & Womens Hosp, Howard Hughes Med Inst, 75 Francis St, Boston, MA 02115 USA

Kuroda, MI
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Howard Hughes Med Inst, 75 Francis St, Boston, MA 02115 USA
[2]
A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome
[J].
Alekseyenko, Artyom A.
;
Peng, Shouyong
;
Larschan, Erica
;
Gorchakov, Andrey A.
;
Lee, Ok-Kyung
;
Kharchenko, Peter
;
McGrath, Sean D.
;
Wang, Charlotte I.
;
Mardis, Elaine R.
;
Park, Peter J.
;
Kuroda, Mitzi I.
.
CELL,
2008, 134 (04)
:599-609

Alekseyenko, Artyom A.
论文数: 0 引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Peng, Shouyong
论文数: 0 引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Childrens Hosp, Childrens Hosp Informat Program, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Larschan, Erica
论文数: 0 引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Gorchakov, Andrey A.
论文数: 0 引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Lee, Ok-Kyung
论文数: 0 引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Kharchenko, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Childrens Hosp, Childrens Hosp Informat Program, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

McGrath, Sean D.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Genet, St Louis, MO 63108 USA
Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Wang, Charlotte I.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Mardis, Elaine R.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Genet, St Louis, MO 63108 USA
Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Park, Peter J.
论文数: 0 引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Childrens Hosp, Childrens Hosp Informat Program, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Kuroda, Mitzi I.
论文数: 0 引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
[3]
The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association
[J].
Allahverdi, Abdollah
;
Yang, Renliang
;
Korolev, Nikolay
;
Fan, Yanping
;
Davey, Curt A.
;
Liu, Chuan-Fa
;
Nordenskioeld, Lars
.
NUCLEIC ACIDS RESEARCH,
2011, 39 (05)
:1680-1691

Allahverdi, Abdollah
论文数: 0 引用数: 0
h-index: 0
机构:
Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

Yang, Renliang
论文数: 0 引用数: 0
h-index: 0
机构:
Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

Korolev, Nikolay
论文数: 0 引用数: 0
h-index: 0
机构:
Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

Fan, Yanping
论文数: 0 引用数: 0
h-index: 0
机构:
Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

Davey, Curt A.
论文数: 0 引用数: 0
h-index: 0
机构:
Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

Liu, Chuan-Fa
论文数: 0 引用数: 0
h-index: 0
机构:
Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

Nordenskioeld, Lars
论文数: 0 引用数: 0
h-index: 0
机构:
Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore
[4]
Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster
[J].
Bai, X.
;
Larschan, E.
;
Kwon, S. Y.
;
Badenhorst, P.
;
Kurodat, M. I.
.
GENETICS,
2007, 176 (03)
:1491-1499

Bai, X.
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Howard Hughes Med Inst, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Larschan, E.
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Howard Hughes Med Inst, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

论文数: 引用数:
h-index:
机构:

Badenhorst, P.
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Howard Hughes Med Inst, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Kurodat, M. I.
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Howard Hughes Med Inst, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
[5]
Expression and purification of recombinant yeast Ada2/Ada3/Gcn5 and Piccolo NuA4 histone acetyltransferase complexes
[J].
Barrios, Adam
;
Selleck, William
;
Hnatkovich, Brian
;
Kramer, Ryan
;
Sermwittayawong, Decha
;
Tan, Song
.
METHODS,
2007, 41 (03)
:271-277

Barrios, Adam
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA

Selleck, William
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA

Hnatkovich, Brian
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA

Kramer, Ryan
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA

Sermwittayawong, Decha
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA

Tan, Song
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA Penn State Univ, Ctr Gene Regulat, Dept Biochem & Mol Biol, Althouse Lab 108, University Pk, PA 16802 USA
[6]
Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing
[J].
Bell, Oliver
;
Schwaiger, Michaela
;
Oakeley, Edward J.
;
Lienert, Florian
;
Beisel, Christian
;
Stadler, Michael B.
;
Schuebeler, Dirk
.
NATURE STRUCTURAL & MOLECULAR BIOLOGY,
2010, 17 (07)
:894-U1

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Oakeley, Edward J.
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst Biomed Res, Basel, Switzerland Friedrich Miescher Inst Biomed Res, Basel, Switzerland

Lienert, Florian
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst Biomed Res, Basel, Switzerland Friedrich Miescher Inst Biomed Res, Basel, Switzerland

Beisel, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
ETH, Dept Biosyst Sci & Engn, Basel, Switzerland Friedrich Miescher Inst Biomed Res, Basel, Switzerland

Stadler, Michael B.
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst Biomed Res, Basel, Switzerland Friedrich Miescher Inst Biomed Res, Basel, Switzerland

Schuebeler, Dirk
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst Biomed Res, Basel, Switzerland Friedrich Miescher Inst Biomed Res, Basel, Switzerland
[7]
Mechanical disruption of individual nucleosomes reveals a reversible multistage release of DNA
[J].
Brower-Toland, BD
;
Smith, CL
;
Yeh, RC
;
Lis, JT
;
Peterson, CL
;
Wang, MD
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2002, 99 (04)
:1960-1965

Brower-Toland, BD
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Dept Phys, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA

Smith, CL
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Dept Phys, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA

Yeh, RC
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Dept Phys, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA

Lis, JT
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Dept Phys, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA

Peterson, CL
论文数: 0 引用数: 0
h-index: 0
机构: Cornell Univ, Dept Phys, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA

Wang, MD
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Phys, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA Cornell Univ, Dept Phys, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA
[8]
ENTROPIC ELASTICITY OF LAMBDA-PHAGE DNA
[J].
BUSTAMANTE, C
;
MARKO, JF
;
SIGGIA, ED
;
SMITH, S
.
SCIENCE,
1994, 265 (5178)
:1599-1600

BUSTAMANTE, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,DEPT CHEM,EUGENE,OR 97403

MARKO, JF
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,DEPT CHEM,EUGENE,OR 97403

SIGGIA, ED
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,DEPT CHEM,EUGENE,OR 97403

SMITH, S
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,DEPT CHEM,EUGENE,OR 97403
[9]
The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization
[J].
Carre, Clement
;
Ciurciu, Anita
;
Komonyi, Orban
;
Jacquier, Caroline
;
Fagegaltier, Delphine
;
Pidoux, Josette
;
Tricoire, Herve
;
Tora, Laszlo
;
Boros, Imre M.
;
Antoniewski, Christophe
.
EMBO REPORTS,
2008, 9 (02)
:187-192

Carre, Clement
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France

Ciurciu, Anita
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Biochem, Biol Res Ctr, H-6726 Szeged, Hungary Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France

Komonyi, Orban
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Szeged, Dept Biochem, H-6726 Szeged, Hungary Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France

Jacquier, Caroline
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France

Fagegaltier, Delphine
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France

Pidoux, Josette
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France

Tricoire, Herve
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Jacques Monod, Dept Dev Biol, F-75251 Paris, France Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France

Tora, Laszlo
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR 7104, IGBMC, F-67404 Illkirch Graffenstaden, France Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France

Boros, Imre M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Szeged, Dept Biochem, H-6726 Szeged, Hungary Inst Pasteur, Dept Dev Biol, CNRS, URA 2578, F-75724 Paris 15, France

论文数: 引用数:
h-index:
机构:
[10]
A critical epitope for substrate recognition by the nucleosome remodeling ATPase ISWI
[J].
Clapier, CR
;
Nightingale, KP
;
Becker, PB
.
NUCLEIC ACIDS RESEARCH,
2002, 30 (03)
:649-655

Clapier, CR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany

Nightingale, KP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany

Becker, PB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany