Involvement of central noradrenaline, serotonin and dopamine system in the antidepressant activity of fruits of Solanum torvum (Solanaceae)

被引：9

作者：

Momin, Rehan ^{[1
]}

Mohan, Mahalaxmi ^{[1
]}

机构：

[1] MGV Coll Pharm, Dept Pharmacol, Panchavati, Maharashtra, India

来源：

NATURAL PRODUCT RESEARCH | 2012年 / 26卷 / 05期

关键词：

depression; FST; monoamine oxidase; S; torvum; TST; FORCED SWIMMING TEST; TAIL SUSPENSION TEST; LEAVES; MICE; GLYCOSIDES;

D O I：

10.1080/14786419.2010.495072

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The methanolic extract (ME) of Solanum torvum seeds and its ethyl acetate fraction (EAF) were investigated for their antidepressant activity using behavioral (forced swim test, FST and tail suspension test, TST) and biochemical (monoamine oxidase, MAO reduced activity) tests. ME (10, 30 and 100 mg kg(-1)) and EAF (10 and 30 mg kg(-1)) dose dependently inhibited the immobility period, increased noradrenaline, serotonin and dopamine levels and inhibited the MAO enzymes in FST and TST using mice. Furthermore, we have observed antagonism between the threshold dose of ME (30 and 100 mg kg(-1)) and EAF (10 and 30 mg kg(-1)) with antagonists on behaviour mediated by neurotransmitters noradrenaline, serotonin and dopamine. MAO-A inhibition was more prominent as compared to MAO-B inhibition. The study provides evidence for antidepressant actions of S. torvum.

引用

页码：416 / 422

页数：7

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