A novel fast-acting sub-perception spinal cord stimulation therapy enables rapid onset of analgesia in patients with chronic pain

被引:37
作者
Metzger, Clark S. [1 ]
Hammond, M. Blake [1 ]
Paz-Solis, Jose F. [2 ]
Newton, William J. [3 ]
Thomson, Simon J. [4 ]
Pei, Yu [5 ]
Jain, Roshini [5 ]
Moffitt, Michael [5 ]
Annecchino, Luca [5 ]
Doan, Que [5 ]
机构
[1] NeuroMicroSpine, 9400 Univ Pkwy,309, Pensacola, FL 32514 USA
[2] Univ Hosp La Paz, Dept Neurosurg, Madrid, Spain
[3] Intervent Spine & Pain Ctr, Manchester, TN USA
[4] NHS, Pain Management & Neuromodulat, Basildon & Thurrock Univ Hosp, Basildon, England
[5] Boston Sci, Div Neuromodulat, Valencia, CA USA
关键词
Chronic pain; spinal cord stimulation; SCS; fast-acting sub-perception therapy; FAST; sub-perception; paresthesia-free;
D O I
10.1080/17434440.2021.1890580
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Background: Treating chronic pain using sub-perception Spinal Cord Stimulation (SCS) does not elicit paresthesia but is associated with long analgesic 'wash-in' (i.e. duration until maximum pain relief) and prolonged assessment of therapy. We describe the attainment of clinically meaningful and rapid-onset analgesic outcomes using a novel sub-perception SCS approach. Methods: This observational case-series evaluated patients implanted with an SCS device for chronic pain, who underwent re-programming utilizing a new methodology in which paresthesia was used to guide sub-perception stimulation field targeting at specific parameters including charge-balanced symmetrical pulses at 90 Hz (termed Fast-Acting Sub-Perception Therapy, FAST). Pain scores (NRS) were collected as reported per standard-of-care from patient charts. Results: Mean overall pain score at baseline was 8.4 +/- 0.2 (n = 41). After activation of FAST, a 7.1-point reduction in overall pain score was (1.3 +/- 0.2, p < 0.0001) reported within 11.2 +/- 1.9 minutes (n = 34). This decrease in pain score was sustained out to 3-month (1.6 +/- 0.3, n = 26) and 6-month follow-up (1.7 +/- 0.4, n = 18). At last follow up (mean = 223 +/- 132 days), a pain score of 1.6 +/- 0.3, n = 30 was determined. Conclusions: After FAST implementation, a profound analgesic response, requiring substantially less energy than conventional sub-perception methodologies, was observed. This rapid analgesic onset achieved with the novel FAST technique suggests the potential for an alternative mechanism of action(s) of sub-perception SCS.
引用
收藏
页码:299 / 306
页数:8
相关论文
共 30 条
[1]   The Use of 10-Kilohertz Spinal Cord Stimulation in a Cohort of Patients With Chronic Neuropathic Limb Pain Refractory to Medical Management [J].
Al-Kaisy, Adnan ;
Palmisani, Stefano ;
Smith, Tom ;
Harris, Stephany ;
Pang, David .
NEUROMODULATION, 2015, 18 (01) :18-23
[2]  
Bradley K, 2006, PAIN MED, V7, P27
[3]   Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy [J].
Chakravarthy, Krishnan ;
Richter, Hira ;
Christo, Paul J. ;
Williams, Kayode ;
Guan, Yun .
NEUROMODULATION, 2018, 21 (01) :10-18
[4]  
De Carolis G, 2017, PAIN PHYSICIAN, V20, P331
[5]   Differential modulation of excitatory and inhibitory populations of superficial dorsal horn neurons in lumbar spinal cord by Aβ-fiber electrical stimulation [J].
Fan, Wei ;
Sdrulla, Andrei D. .
PAIN, 2020, 161 (07) :1650-1660
[6]   Morphometry of human superficial dorsal and dorsolateral column fibres: significance to spinal cord stimulation [J].
Feirabend, HKP ;
Choufoer, H ;
Ploeger, S ;
Holsheimer, J ;
van Gool, JD .
BRAIN, 2002, 125 :1137-1149
[7]  
Foster A., 2006, CNS 56 ANN M CHIC
[8]  
Gilbert JE., 2021, SOC NEUROSCIENCE GLO
[9]   Mechanisms of spinal cord stimulation for the treatment of pain: Still in the dark after 50 years [J].
Jensen, Melanie P. ;
Brownstone, Robert M. .
EUROPEAN JOURNAL OF PAIN, 2019, 23 (04) :652-659
[10]   Pain regulation by non-neuronal cells and inflammation [J].
Ji, Ru-Rong ;
Chamessian, Alexander ;
Zhang, Yu-Qiu .
SCIENCE, 2016, 354 (6312) :572-577