Body mass index as a phenotypic expression of adiposity: quantitative contribution of muscularity in a population-based sample

被引:106
作者
Heymsfield, S. B. [1 ]
Scherzer, R. [2 ,3 ]
Pietrobelli, A. [4 ]
Lewis, C. E. [5 ]
Grunfeld, C. [2 ,3 ]
机构
[1] Merck & Co Inc, Global Ctr Sci Affairs, Rahway, NJ 07065 USA
[2] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[3] Vet Affairs Med Ctr, Metab Sect, San Francisco, CA 94121 USA
[4] Univ Verona, Sch Med, Pediat Unit, I-37100 Verona, Italy
[5] Univ Alabama Birmingham, Birmingham, AL USA
关键词
body composition; ethnicity; body mass index; ARTERY RISK DEVELOPMENT; SKELETAL-MUSCLE MASS; YOUNG-ADULTS; FAT DISTRIBUTION; TISSUE; ASSOCIATION; OBESITY; WEIGHT; WOMEN; MEN;
D O I
10.1038/ijo.2009.184
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Although widely applied as a phenotypic expression of adiposity in population and gene-search studies, body mass index (BMI) is also acknowledged to reflect muscularity even though relevant studies directly measuring skeletal muscle (SM) mass are lacking. The current study aimed to fill this important gap by applying advanced imaging methods to test the hypothesis that, after controlling first for adiposity, SM mass is also a significant determinant of BMI in a population-based sample. Design: Whole-body magnetic resonance imaging scans were completed in Coronary Artery Risk Development in Young Adults study subjects aged 33-45 years. Physical activity (PA) levels, alcohol intake and adequacy of food intake were assessed by standardized questionnaires. Subjects: The study included 58 African-American ( AA) and 78 Caucasian ( C) men; and 63 AA and 64 C women. Measurements: Whole-body adipose tissue ( AT) and SM volumes. Results: AT was significantly predicted by not only BMI, but also PA and alcohol intake with total model R-2's of 0.68 (P<0.0001) for men and 0.89 (P<0.0001) for women. Men had more SM than AT at all levels of BMI whereas SM predominated in women at lower BMIs (C<26 kg/m(2); AA<28 kg/m(2)). In men, both AT and SM contributed a similar proportion of between-subject variation in BMI. In contrast, in women AT contributed similar to 30% more than SM to the variation in BMI. Developed allometric models indicated SM associations with AT, PA and race after adjusting for height. There was little association of age, lifestyle factors or race with BMI after controlling for both AT and SM. Conclusion: Variation in muscularity provides a mechanistic basis for the previously observed nonspecificity of BMI as a phenotypic expression of adiposity. These quantitative observations have important implications when choosing adiposity measures in population and gene-search studies. International Journal of Obesity ( 2009) 33, 1363-1373; doi: 10.1038/ijo.2009.184; published online 22 September 2009
引用
收藏
页码:1363 / 1373
页数:11
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