Clinicopathological Characteristics of Low-Grade Appendiceal Mucinous Neoplasm

被引：9

作者：

Yamaguchi, Tatsuro ^{[1
]}

Murata, Kohei ^{[2
]}

Shiota, Tetsuya ^{[3
]}

Takeyama, Hiroshi ^{[4
]}

Noura, Shingo ^{[5
]}

Sakamoto, Kazuhiro ^{[6
]}

Suto, Takeshi ^{[7
]}

Takii, Yasumasa ^{[8
]}

Nagasaki, Toshiya ^{[9
]}

Takeda, Takashi ^{[10
]}

Fujii, Makoto ^{[11
,12
]}

Kagawa, Yoshinori ^{[2
]}

Mizushima, Tsunekazu ^{[13
]}

Ohno, Yuko ^{[12
]}

Yao, Takashi ^{[14
]}

Kishimoto, Mitsuo ^{[15
]}

Sugihara, Kenichi ^{[16
]}

机构：

[1] Tokyo Metropolitan Canc & Infect Dis Ctr Komagome, Dept Surg, Tokyo, Japan

[2] Kansai Rosai Hosp, Dept Surg, Amagasaki, Hyogo, Japan

[3] Kobe City Nishi Kobe Med Ctr, Dept Surg, Gastroenterol Surg, Kobe, Hyogo, Japan

[4] Minoh City Hosp, Dept Gastroenterol Surg, Mino, Japan

[5] Toyonaka City Hosp, Dept Surg, Toyonaka, Osaka, Japan

[6] Juntendo Univ, Dept Coloproctol Surg, Fac Med, Tokyo, Osaka, Japan

[7] Yamagata Prefectural Cent Hosp, Dept Gastroenterol Surg, Yamagata, Japan

[8] Niigata Canc Ctr Hosp, Dept Gastroenterol Surg, Niigata, Japan

[9] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Gastroenterol Surg, Tokyo, Japan

[10] Osaka Univ, Grad Sch Med, Dept Gastroenterol Surg, Suita, Osaka, Japan

[11] Kobe Womens Univ, Fac Nursing, Kobe, Hyogo, Japan

[12] Osaka Univ, Grad Sch Med, Dept Math Hlth Sci, Suita, Osaka, Japan

[13] Osaka Univ, Dept Gastroenterol Surg & Therapeut Inflammatory, Grad Sch Med, Suita, Osaka, Japan

[14] Juntendo Univ, Dept Human Pathol, Grad Sch Med, Tokyo, Japan

[15] Kyoto City Hosp, Dept Surg Pathol, Kyoto, Japan

[16] Tokyo Med & Dent Univ, Tokyo, Japan

来源：

DIGESTIVE SURGERY | 2021年 / 38卷 / 03期

关键词：

Appendiceal neoplasms; Low-grade appendiceal mucinous neoplasms; Appendiceal mucinous neoplasms; Low-grade appendiceal mucinous neoplasm; PSEUDOMYXOMA PERITONEI; CYTOREDUCTIVE SURGERY; SURVIVAL; CLASSIFICATION;

D O I：

10.1159/000513973

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Introduction: Recently, "low-grade appendiceal mucinous neoplasms" (LAMNs) have been proposed as one subtype of appendiceal mucinous neoplasms, characterized by a villous or flat proliferation of mucinous epithelium with low-grade cytologic atypia. The aim of this study was to clarify the clinicopathological characteristics of LAMN. Methods: In this multi-institutional cohort study, we retrospectively analyzed the clinicopathological characteristics in appendiceal neoplasms patients who underwent treatment from 2000 to 2017. Results: In total, 922 patients were enrolled, with 279 (30.3%) cases of LAMN, and 93 (10.1%) cases of non-LAMN disease. In comparison with patients with non-LAMN disease, those with LAMN had significantly lower levels of CA19-9 (p = 0.045), a lower frequency of T4 tumors (p < 0.0001), a lower frequency of lymph node metastasis (p < 0.0001), and a lower frequency of distant metastasis (p < 0.0001). Survival analysis revealed that patients with LAMN had a significantly better prognosis than did those with non-LAMN disease (p < 0.001). Among the patients with distant metastasis, those with LAMN had a significantly better prognosis than did those with non-LAMN disease (p = 0.0020), but among the patients without distant metastasis, the difference between the 2 groups was not significant (p = 0.26). However, among patients who underwent complete resection, the difference in prognosis between the 2 groups was not significant (p = 0.10). Conclusions: A multicenter retrospective study revealed that the clinicopathological characteristics of LAMN was different from those of non-LAMN.

引用

页码：222 / 229

页数：8

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