Efficacy of α-lipoic acid against diabetic cataract in rat

被引：29
作者：
Kojima, Masami
Sun, Li
Hata, Ikuho
Sakamoto, Yasuo
Sasaki, Hiroshi
Sasaki, Kazuyuki
机构：
[1] Kanazawa Med Univ, Dept Ophthalmol, Uchinada, Ishikawa 9200293, Japan
[2] Kanazawa Med Univ, Med Res Inst, Div Vis Res Environm Hlth, Uchinada, Ishikawa 9200293, Japan
来源：
JAPANESE JOURNAL OF OPHTHALMOLOGY | 2007年 / 51卷 / 01期
关键词：
antioxidant; diabetic cataract; alpha-lipoic acid; lipoic acid; rat;
D O I：
10.1007/s10384-006-0384-3
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: alpha-Lipoic acid (LA) is well known as a powerful antioxidant. The efficacy of dihydrolipoate-LA for oral administration against streptozotocin (STZ)-induced diabetic cataract in rat was investigated. Methods: Rats were divided into three groups, control, diabetes mellitus (DM), and DM treated with LA (DM+LA). Diabetes was induced by intravenous injection of 50mg/kg STZ. DM+LA rats were fed 30mg/rat per day LA in their diet. Lens changes were assessed using Scheimpflug images (EAS-1000) and by measuring light-scattering intensity. Results: Increase in lens light scattering was less (P < 0.05) in DM+LA rats than in DM rats 5 weeks after induction of diabetes. DM rats had the highest and control rats the lowest blood glucose levels at every measurement point up to 111 days (P < 0.05). Conclusion: LA treatment delayed development and progression of cataract in rats with streptozotocin-induced diabetes.
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页码：10 / 13
页数：4
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