Opposing effects of adiponectin receptors 1 and 2 on energy metabolism

被引：206
作者：
Bjursell, Mikael
Ahnmark, Andrea
Bohlooly-Y, Mohammad
William-Olsson, Lena
Rhedin, Magdalena
Peng, Xiao-Rong
Ploj, Karolina
Gerdin, Anna-Karin
Arnerup, Gunnel
Elmgren, Anders
Berg, Anna-Lena
Oscarsson, Jan
Linden, Daniel [1 ]
机构：
[1] AstraZeneca R&D, Dept Integrat Pharmacol, SE-43183 Molndal, Sweden
[2] Univ Gothenburg, Dept Physiol Endocrinol, Sahlgrenska Acad, Gothenburg, Sweden
[3] AstraZeneca R&D, Safety Assessment Sweden, Sodertalje, Sweden
[4] Univ Gothenburg, Wallenberg Lab Cardiovasc Res, Sahlgrenska Acad, Gothenburg, Sweden
来源：
DIABETES | 2007年 / 56卷 / 03期
关键词：
D O I：
10.2337/db06-1432
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The adipocyte-derived hormone adiponectin regulates glucose and lipid metabolism and influences the risk for developing obesity, type 2 diabetes, and cardiovascular disease. Adiponectin binds to two different seven-transmembrane domain receptors termed AdipoR1 and AdipoR2. To study the physiological importance of these receptors, AdipoR1 gene knockout mice (AdipoR1(-/-)) and AdipoR2 gene knockout mice ('AdipoR2(-/-)) were generated. AdipoR1(-/-) mice showed increased adiposity associated with decreased glucose tolerance, spontaneous locomotor activity, and energy expenditure. However, AdipoR2(-/-) mice were lean and resistant to high-fat diet-induced obesity associated with improved glucose tolerance and higher spontaneous locomotor activity and energy expenditure and reduced plasma cholesterol levels. Thus, AdipoR1 and AdipoR2 are clearly involved in energy metabolism but have opposing effects.
引用
收藏
页码：583 / 593
页数：11
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