Role of EZH2 in cell lineage determination and relative signaling pathways

被引：39

作者：

Batool, Aalia ^{[1
,2
]}

Jin, Cheng ^{[1
]}

Liu, Yi-Xun ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2019年 / 24卷

基金：

中国国家自然科学基金;

关键词：

Organogenesis; PCR2; H3K27me3; Cell Fate Decision; Embryonic Development; Review; POLYCOMB-GROUP GENE; GROUP PROTEIN EZH2; STEM-CELLS; HEMATOPOIETIC STEM; HISTONE METHYLTRANSFERASE; SKELETAL-MUSCLE; DEVELOPMENTAL REGULATORS; GERMINAL CENTER; WEAVER SYNDROME; TARGET GENES;

D O I：

10.2741/4760

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enhancer of zeste homolog 2 (EZH2), a catalytic component of polycomb repressive complex 2 (PRC2), epigenetically regulates chromatin structure and gene expression through trimethylation at histone H3K27 and recruitment of DNA methyltransferases for gene silencing. Despite extensive studies of the role of EZH2 in cancer progression and malignancy, increasing evidences suggest that EZH2 plays a critical role in stem cells renewal, maintenance, and differentiation into specific cell lineages. Here, we reviewed the update information regarding how EZH2 contributes to stem cell maintenance and cell lineage determination (including gonadogenesis, neurogenesis, myogenesis, osteogenesis, hematopoiesis, lymphopoiesis, adipogenesis, epidermal differentiation and hepatogenesis), and the regulation of EZH2 by phosphorylation and different signaling pathways.

引用

页码：947 / 960

页数：14

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