Metabonomics in pharmaceutical discovery and development

被引：74
作者：
Robertson, Donald G. [1 ]
Reily, Michael D. [1 ]
Baker, J. David [1 ]
机构：
[1] Pfizer Global Res & Dev, Metabon Evaluat Grp, Ann Arbor, MI 48105 USA
来源：
JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 02期
关键词：
metabonomics; NMR spectroscopy; mass spectrometry; chemometrics; pharmaceutical development;
D O I：
10.1021/pr060535c
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Metabonomics has emerged as a key technology in pharmaceutical discovery and development, evolving as the small molecule counterpart of transcriptomics and proteomics. In drug discovery laboratories, metabonomics aids in target identification, phenotyping, and the understanding of the biochemical basis of disease and toxicity. This review focuses on three areas where metabonomics is used in the industry: (1) analytical considerations, (2) chemometric and statistical concerns, and (3) biological aspects and applications.
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收藏
页码：526 / 539
页数：14
相关论文
共 163 条
[41]  
Ernst R, 1990, PRINCIPLES NUCL MAGN
[42]   The gut microbiota and lipid metabolism: Implications for human health and coronary heart disease [J].
Fava, F. ;
Lovegrove, J. A. ;
Gitau, R. ;
Jackson, K. G. ;
Tuohy, K. M. .
CURRENT MEDICINAL CHEMISTRY, 2006, 13 (25) :3005-3021
[43]   Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks [J].
Fiehn, O .
COMPARATIVE AND FUNCTIONAL GENOMICS, 2001, 2 (03) :155-168
[44]   NMR-SPECTROSCOPY AS A NOVEL-APPROACH TO THE MONITORING OF RENAL-TRANSPLANT FUNCTION [J].
FOXALL, PJD ;
MELLOTTE, GJ ;
BENDING, MR ;
LINDON, JC ;
NICHOLSON, JK .
KIDNEY INTERNATIONAL, 1993, 43 (01) :234-245
[45]   750 MHZ 1H-NMR SPECTROSCOPY OF HUMAN BLOOD-PLASMA [J].
FOXALL, PJD ;
SPRAUL, M ;
FARRANT, RD ;
LINDON, LC ;
NEILD, GH ;
NICHOLSON, JK .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1993, 11 (4-5) :267-276
[46]  
GARTLAND KP, 1990, BIOMED ANAL, V8, P963
[47]   BIOCHEMICAL-CHARACTERIZATION OF PARA-AMINOPHENOL-INDUCED NEPHROTOXIC LESIONS IN THE F344 RAT [J].
GARTLAND, KPR ;
BONNER, FW ;
TIMBRELL, JA ;
NICHOLSON, JK .
ARCHIVES OF TOXICOLOGY, 1989, 63 (02) :97-106
[48]   PROTON NMR-STUDIES ON THE EFFECTS OF URANYL-NITRATE ON THE BIOCHEMICAL-COMPOSITION OF RAT URINE AND PLASMA [J].
GARTLAND, KPR ;
ANTHONY, ML ;
BEDDELL, CR ;
LINDON, JC ;
NICHOLSON, JK .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1990, 8 (8-12) :951-954
[49]   Directly coupled high-performance liquid chromatography and nuclear magnetic resonance spectroscopic with chemometric studies on metabolic variation in Sprague-Dawley rats [J].
Gavaghan, CL ;
Nicholson, JK ;
Connor, SC ;
Wilson, ID ;
Wright, B ;
Holmes, E .
ANALYTICAL BIOCHEMISTRY, 2001, 291 (02) :245-252
[50]   An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences:: application to the C57BL10J and Alpk:ApfCD mouse [J].
Gavaghan, CL ;
Holmes, E ;
Lenz, E ;
Wilson, ID ;
Nicholson, JK .
FEBS LETTERS, 2000, 484 (03) :169-174
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