Metabonomics in pharmaceutical discovery and development

被引：74

作者：

Robertson, Donald G. ^{[1
]}

Reily, Michael D. ^{[1
]}

Baker, J. David ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Metabon Evaluat Grp, Ann Arbor, MI 48105 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 02期

关键词：

metabonomics; NMR spectroscopy; mass spectrometry; chemometrics; pharmaceutical development;

D O I：

10.1021/pr060535c

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabonomics has emerged as a key technology in pharmaceutical discovery and development, evolving as the small molecule counterpart of transcriptomics and proteomics. In drug discovery laboratories, metabonomics aids in target identification, phenotyping, and the understanding of the biochemical basis of disease and toxicity. This review focuses on three areas where metabonomics is used in the industry: (1) analytical considerations, (2) chemometric and statistical concerns, and (3) biological aspects and applications.

引用

页码：526 / 539

页数：14

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