The development of adult innate lymphoid cells

被引：36

作者：

Yang, Qi ^{[1
,2
]}

Bhandoola, Avinash ^{[1
]}

机构：

[1] NCI, T Cell Biol & Dev Unit, Lab Genome Integr, Ctr Canc Res, Bethesda, MD 20892 USA

[2] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2016年 / 39卷

基金：

美国国家卫生研究院;

关键词：

NATURAL-KILLER-CELLS; TRANSCRIPTION FACTOR GATA3; ROR-GAMMA-T; MURINE BONE-MARROW; FACTOR BCL11B; AIRWAY HYPERREACTIVITY; FACTOR TOX; LINEAGE; TCF-1; DIFFERENTIATION;

D O I：

10.1016/j.coi.2016.01.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphoid cells (ILC) area specialized family of effector lymphocytes that transcriptionally and functionally mirror effector subsets of T cells, but differ from T cells in that they lack clonally distributed adaptive antigen receptors. Our understanding of this family of lymphocytes is still in its infancy. In this review, we summarize current understanding and discuss recent insights into the cellular and molecular events that occur during early ILC development in adult mice. We discuss how these events overlap and diverge with the early development of adaptive T cells, and how they may influence the molecular and functional properties of mature ILC.

引用

页码：114 / 120

页数：7

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