Sulfoxonium Ylides as Carbene Precursors: Rhodium(III)-Catalyzed Sequential C-H Functionalization, Selective Enol Oxygen-Atom Nucleophilic Addition, and Hydrolysis

被引：35

作者：

Huang, Yuanqiong ^{[1
]}

Lyu, Xueli ^{[1
]}

Song, Hongjian ^{[1
]}

Wang, Qingmin ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Chem, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 22期

基金：

中国国家自然科学基金;

关键词：

nucleophilic addition; oxazolines; Rhodium; regioselectivity; ylides; N BOND FORMATION; BENZOIC-ACIDS; ACTIVATION; ISOCOUMARINS; CYCLIZATION; ANNULATION; ALKYNES; ACYLMETHYLATION; SILYLATION; OXAZOLINES;

D O I：

10.1002/adsc.201900861

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, we report a protocol for Rh(III)-catalyzed annulation reactions between oxazolines and sulfoxonium ylides via a sequence involving C-H activation, selective enol oxygen-atom nucleophilic addition, and hydrolysis. This practical, operationally simple protocol has a wide substrate range, excellent regioselectivity, and moderate to good yields.

引用

页码：5272 / 5276

页数：5

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