Catalytic antibodies in the bone marrow and other organs of Th mice during spontaneous development of experimental autoimmune encephalomyelitis associated with cell differentiation

被引：7

作者：

Aulova, Kseniya S. ^{[1
]}

Urusov, Andrey E. ^{[1
]}

Toporkova, Ludmila B. ^{[2
]}

Sedykh, Sergey E. ^{[1
]}

Shevchenko, Yuliya A. ^{[2
]}

Tereshchenko, Valery P. ^{[2
]}

Sennikov, Sergei V. ^{[2
]}

Budde, Thomas ^{[3
]}

Meuth, Sven G. ^{[4
]}

Orlovskaya, Irina A. ^{[2
]}

Nevinsky, Georgy A. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk, Russia

[2] Russian Acad Sci, Inst Clin Immunol, Siberian Branch, Novosibirsk, Russia

[3] Westfalische Wilhelms Univ, Inst Physiol 1, Robert Koch Str 27a, D-48149 Munster, Germany

[4] Westfalische Wilhelms Univ, Dept Neurol, Albert Schweitzer Campus 1, D-48149 Munster, Germany

来源：

MOLECULAR BIOLOGY REPORTS | 2021年 / 48卷 / 02期

基金：

俄罗斯科学基金会;

关键词：

Th mice; Development of experimental autoimmune encephalomyelitis; Hematopoietic stem cells differentiation; Lymphocyte proliferation in different organs; Catalytic antibodies; MYELIN BASIC-PROTEIN; MULTIPLE-SCLEROSIS; HYDROLYZING ANTIBODIES; DIFFERENT ABZYMES; COLONY FORMATION; B-CELLS; SERA; IGGS; DNA; AUTOANTIBODIES;

D O I：

10.1007/s11033-020-06117-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exact mechanisms of autoimmune disease development are still yet unknown. However, it is known that the development of autoimmune diseases is associated with defects in the immune system, namely, the violation of the bone marrow hematopoietic stem cells (HSCs) differentiation profiles. Different characteristics of autoimmune reaction development in experimental autoimmune encephalomyelitis (EAE) prone Th mice characterizing T-lymphocytes response were analyzed using standard approaches. Profiles of several HSCs differentiation of bone marrow (BFU-E, CFU-E, CFU-GM, CFU-GEMM, T- and B-lymphocytes) of Th male and female mice during spontaneous development of EAE were noticeably different. Patterns of total lymphocytes, B- and T-cells proliferation in several different organs (bone marrow, blood, spleen, thymus, and lymph nodes) were also remarkably different. In addition, there were in time noticeable differences in their changes for some organs of male and female mice. Characters of changes in the profiles of CD4 and CD8 cells proliferation in some organs not always coincide with those for total T lymphocytes. The changes in the differentiation profiles of HSCs and the level of lymphocytes proliferation in the bone marrow and other organs were associated with the increase in the concentration of antibodies against DNA, myelin basic protein, and myelin oligodendrocyte glycoprotein, and catalytic antibodies hydrolyzing these substrates. Despite some differences in changes in the analyzed parameters, in general, the spontaneous development of EAE in male and female mice occurs to some extent in a comparable way.

引用

页码：1055 / 1068

页数：14

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