Novel 6-substituted benzothiazol-2-yl indolo[1,2-c]quinazolines and benzimidazo[1,2-c]quinazolines

被引：44
|
作者：
Frère, S
Thiéry, V
Bailly, C
Besson, T
机构：
[1] Univ La Rochelle, LGPC UPRES EA3169, Grp Chim Organ, UFR Sci Fondamentales & Sci Ingn, F-17042 La Rochelle 1, France
[2] Inst Rech Canc, INSERM U524, F-59045 Lille, France
来源：
TETRAHEDRON | 2003年 / 59卷 / 06期
关键词：
D O I：
10.1016/S0040-4020(02)01593-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthetic route to and a preliminary biological evaluation of novel indolo[1,2-c]quinazolines (8) and benzimidazo[1,2-c]quinazolines (9) are described. The products were obtained by condensation of the appropriate diamines (e.g. 2-(2-aminophenyl)indole or 2-(2-aminophenyl)benzimidazole) with 2-cyanobenzothiazoles. This work further demonstrates the general applicability of microwaves for a facile and rapid access to original heterocycles with potential pharmaceutical value. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：773 / 779
页数：7
相关论文
共 50 条
  • [21] Novel Polycarbo-Substituted Imidazo[1,2-c] quinazolines: Synthesis and Cytotoxicity Study
    Khoza, Tebogo Ankie
    Makhafola, Tshepiso Jan
    Mphahlele, Malose Jack
    MOLECULES, 2015, 20 (12) : 22520 - 22533
  • [22] Condition-Dependent Selective Synthesis of Indolo[1,2-c]quinazolines and Indolo[3,2-c]quinolines from and Sulfoxonium Ylides
    Chen, Guang
    Cai, Xinyuan
    Zhang, Xinying
    Fan, Xuesen
    JOURNAL OF ORGANIC CHEMISTRY, 2022, 87 (15): : 9815 - 9828
  • [23] Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
    Lyakhova, Elena A.
    Gusyeva, Yulia A.
    Nekhoroshkova, Julia V.
    Shafran, Lev M.
    Lyakhov, Sergey A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (08) : 3305 - 3312
  • [24] Microwave - Assisted Synthesis of a Library of Pyrrolo[1,2-c]quinazolines
    Georgescu, Emilian
    Dumitrascu, Florea
    Georgescu, Florentina
    Draghici, Constantin
    Dumitrescu, Denisa
    REVISTA DE CHIMIE, 2019, 70 (09): : 3094 - 3099
  • [25] CONVENIENT SYNTHESIS OF 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES
    HARDTMANN, GE
    OTT, H
    JOURNAL OF ORGANIC CHEMISTRY, 1974, 39 (24): : 3599 - 3600
  • [26] Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect
    Domány, G
    Gizur, T
    Gere, A
    Takács-Novák, K
    Farsang, G
    Ferenczy, GG
    Tárkányi, G
    Demeter, M
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1998, 33 (03) : 181 - 187
  • [27] Synthesis, antibacterial and antioxidant activity of novel 12-(N-arylmethaniminyl)indolo[1,2-c]quinazolines
    Dixit, Aditya
    Pathak, Devender
    Sharma, Gyanendra Kumar
    JOURNAL OF RESEARCH IN PHARMACY, 2019, 23 (03): : 584 - 595
  • [28] Synthesis of quinazolines and imidazo[1,2-c]quinazolines with the aid of a low-valent titanium reagent
    Shi, DQ
    Wang, JX
    Shi, CL
    Rong, LG
    Zhuang, QY
    Hu, HW
    SYNLETT, 2004, (06) : 1098 - 1100
  • [29] NEW METHODOLOGY FOR THE PREPARATION OF PYRROLE AND INDOLE-DERIVATIVES VIA IMINOPHOSPHORANES - SYNTHESIS OF PYRROLO[1,2-A]QUINOXALINES, INDOLO[3,2-C]QUINOLINES AND INDOLO[1,2-C]QUINAZOLINES
    MOLINA, P
    ALAJARIN, M
    VIDAL, A
    TETRAHEDRON, 1990, 46 (03) : 1063 - 1078
  • [30] An efficient one-pot two catalyst system in the construction of 2-substituted benzimidazoles: synthesis of benzimidazo[1,2-c] quinazolines
    Cimarelli, Cristina
    Di Nicola, Matteo
    Diomedi, Simone
    Giovannini, Riccardo
    Hamprecht, Dieter
    Properzi, Roberta
    Sorana, Federico
    Marcantoni, Enrico
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (48) : 11687 - 11695
12345