Novel 6-substituted benzothiazol-2-yl indolo[1,2-c]quinazolines and benzimidazo[1,2-c]quinazolines

被引：44
作者：
Frère, S
Thiéry, V
Bailly, C
Besson, T
机构：
[1] Univ La Rochelle, LGPC UPRES EA3169, Grp Chim Organ, UFR Sci Fondamentales & Sci Ingn, F-17042 La Rochelle 1, France
[2] Inst Rech Canc, INSERM U524, F-59045 Lille, France
来源：
TETRAHEDRON | 2003年 / 59卷 / 06期
关键词：
D O I：
10.1016/S0040-4020(02)01593-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthetic route to and a preliminary biological evaluation of novel indolo[1,2-c]quinazolines (8) and benzimidazo[1,2-c]quinazolines (9) are described. The products were obtained by condensation of the appropriate diamines (e.g. 2-(2-aminophenyl)indole or 2-(2-aminophenyl)benzimidazole) with 2-cyanobenzothiazoles. This work further demonstrates the general applicability of microwaves for a facile and rapid access to original heterocycles with potential pharmaceutical value. (C) 2003 Elsevier Science Ltd. All rights reserved.
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收藏
页码：773 / 779
页数：7
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