Emerging roles of the solute carrier family in pancreatic cancer

被引：37

作者：

Wu, Zijian ^{[1
,2
,3
,4
]}

Xu, Jin ^{[1
,2
,3
,4
]}

Liang, Chen ^{[1
,2
,3
,4
]}

Meng, Qingcai ^{[1
,2
,3
,4
]}

Hua, Jie ^{[1
,2
,3
,4
]}

Wang, Wei ^{[1
,2
,3
,4
]}

Zhang, Bo ^{[1
,2
,3
,4
]}

Liu, Jiang ^{[1
,2
,3
,4
]}

Yu, Xianjun ^{[1
,2
,3
,4
]}

Shi, Si ^{[1
,2
,3
,4
]}

机构：

[1] Fudan Univ Shanghai, Shanghai Canc Ctr, Dept Pancreat Surg, 270 Dong An Rd, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China

[3] Shanghai Pancreat Canc Inst, 270 Dong An Rd, Shanghai 200032, Peoples R China

[4] Fudan Univ, Pancreat Canc Inst, Shanghai, Peoples R China

来源：

CLINICAL AND TRANSLATIONAL MEDICINE | 2021年 / 11卷 / 03期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

pancreatic cancer; solute carrier; tumor biology; NUCLEOSIDE TRANSPORTER 1; PROGNOSTIC-SIGNIFICANCE; DUCTAL ADENOCARCINOMA; GLUCOSE-TRANSPORTER; CELL-GROWTH; C-MYC; EXPRESSION; SLC5A8; GEMCITABINE; SURVIVAL;

D O I：

10.1002/ctm2.356

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is a gastrointestinal tumor with a high mortality rate, and advances in surgical procedures have only resulted in limited improvements in the prognosis of patients. Solute carriers (SLCs), which rank second among membrane transport proteins in terms of abundance, regulate cellular functions, including tumor biology. An increasing number of studies focusing on the role of SLCs in tumor biology have indicated their relationship with pancreatic cancer. The mechanism of SLC transporters in tumorigenesis has been explored to identify more effective therapies and improve survival outcomes. These transporters are significant biomarkers for pancreatic cancer, the functions of which include mainly proliferative signaling, cell death, angiogenesis, tumor invasion and metastasis, energy metabolism, chemotherapy sensitivity and other functions in tumor biology. In this review, we summarize the different roles of SLCs and explain their potential applications in pancreatic cancer treatment.

引用

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