Recent advances in the development of hybrid molecules/designed multiple compounds with antiamnesic properties

被引：56

作者：

Decker, Michael ^{[1
]}

机构：

[1] Inst Pharm, Lehrstuhl Pharmazeut Med Chem, D-07743 Jena, Germany

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 03期

关键词：

hybrid molecules; multiple ligands; AChE inhibitors; serotonin transporter (SERT); monoamine oxidase (MAO); lipoic acid; 5-HT3; receptor; Ca2+-channel blockers;

D O I：

10.2174/138955707780059817

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel compounds have been developed that (in many cases) inhibit cholinesterases and concomitantly interact with at least one further pharmacological target, such as 5-HT3 or H-3 receptors. But also enzymes like monoamine oxidase and the serotonin transporter have been targeted. Hybrid molecules can also incorporate antioxidant or neuronal Ca2+-channel-blocking structures.

引用

页码：221 / 229

页数：9

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