Recent advances in the development of hybrid molecules/designed multiple compounds with antiamnesic properties

被引：56

作者：

Decker, Michael ^{[1
]}

机构：

[1] Inst Pharm, Lehrstuhl Pharmazeut Med Chem, D-07743 Jena, Germany

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 03期

关键词：

hybrid molecules; multiple ligands; AChE inhibitors; serotonin transporter (SERT); monoamine oxidase (MAO); lipoic acid; 5-HT3; receptor; Ca2+-channel blockers;

D O I：

10.2174/138955707780059817

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel compounds have been developed that (in many cases) inhibit cholinesterases and concomitantly interact with at least one further pharmacological target, such as 5-HT3 or H-3 receptors. But also enzymes like monoamine oxidase and the serotonin transporter have been targeted. Hybrid molecules can also incorporate antioxidant or neuronal Ca2+-channel-blocking structures.

引用

页码：221 / 229

页数：9

共 61 条

[1]

ABRAMS MJ, 1990, J NUCL MED, V31, P2022

[2] Development of a new class of nonimidazole histamine H3 receptor ligands with combined inhibitory histamine N-methyltransferase activity [J].

Apelt, J ;

Ligneau, X ;

Pertz, HH ;

Arrang, JM ;

Ganellin, CR ;

Schwartz, JC ;

Schunack, W ;

Stark, H .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (05) :1128-1141

[3]

Barnes N M, 1990, Neuroreport, V1, P253, DOI 10.1097/00001756-199011000-00021

[4] Central nicotinic receptors, neurotrophic factors and neuroprotection [J].

Belluardo, N ;

Mudò, G ;

Blum, M ;

Fuxe, K .

BEHAVIOURAL BRAIN RESEARCH, 2000, 113 (1-2) :21-34

[5] CARDIAC MUSCARINIC BLOCKING AND ATROPINIC BLOCKING EFFECTS OF A TETRAMINE DISULFIDE WITH ALPHA-ADRENOCEPTOR BLOCKING ACTIVITY [J].

BENFEY, BG ;

YONG, MS ;

BELLEAU, B ;

MELCHIORRE, C .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1979, 57 (01) :41-47

[6] The pharmacology of the antioxidant lipoic acid [J].

Biewenga, GP ;

Haenen, GRMM ;

Bast, A .

GENERAL PHARMACOLOGY, 1997, 29 (03) :315-331

[7] Amyloid β-protein (Aβ) assembly:: Aβ40 and Aβ42 oligomerize through distinct pathways [J].

Bitan, G ;

Kirkitadze, MD ;

Lomakin, A ;

Vollers, SS ;

Benedek, GB ;

Teplow, DB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (01) :330-335

[8] Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase [J].

Brühlmann, C ;

Ooms, F ;

Carrupt, PA ;

Testa, B ;

Catto, M ;

Leonetti, F ;

Altomare, C ;

Carotti, A .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (19) :3195-3198

[9] Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands.: Development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties [J].

Cappelli, A ;

Gallelli, A ;

Manini, M ;

Anzini, M ;

Mennuni, L ;

Makovec, F ;

Menziani, MC ;

Alcaro, S ;

Ortuso, F ;

Vomero, S .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (10) :3564-3575

[10] Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice [J].

Capsoni, S ;

Ugolini, G ;

Comparini, A ;

Ruberti, F ;

Berardi, N ;

Cattaneo, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) :6826-6831

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