Malonic acid derivatives as sialyl Lewis X mimetics

被引：12
|
作者：
Toepfer, A
Kretzschmar, G
Schuth, S
Sonnentag, M
机构：
[1] Corporate Research and Technology, Hoechst AG
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(97)00214-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Malonic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays and in vivo. The receptor binding affinity for E- and P-selectins of simple mimetics was found to be comparable to the potency of the tetrasaccharide sialyl Lewis X. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：1317 / 1322
页数：6
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