Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion

被引：135

作者：

Pinilla, Severin ^{[1
]}

Alt, Eckhard ^{[1
]}

Khalek, F. J. Abdul ^{[1
]}

Jotzu, Constantin ^{[1
]}

Muehlberg, Fabian ^{[1
]}

Beckmann, Christoph ^{[1
]}

Song, Yao-Hua ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2009年 / 284卷 / 01期

关键词：

Breast cancer; Mesenchymal stem cell; Invasion; CCL5 (RANTES); Matrixmetalloproteinase; 9; ADIPOSE-TISSUE; STROMAL CELLS; EXPRESSION; MATRIX-METALLOPROTEINASE-9; RECEPTOR; INFLAMMATION; INVOLVEMENT; CCL5/RANTES; METASTASIS; CARCINOMA;

D O I：

10.1016/j.canlet.2009.04.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the present study, we investigated whether human adipose tissue derived stem cells (hASCs) could enhance tumor invasion and whether these hASCs could be a potential source of CCL5. We observed a significant increase in the number of breast cancer cells that invaded the matrigel when Co-cultured with hASCs. We found that hASCs produce CCL5 in the Co-culture and cancer cell invasion was diminished by an antibody against CCL5. Furthermore, cancer cell invasion in the Co-culture was associated with an elevated level of MMP-9 activity. We conclude that CCL5 plays a crucial role for tumor invasion in the interplay of tissue resident stem cells from the fat tissue and breast cancer cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：80 / 85

页数：6