Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion

被引：135

作者：

Pinilla, Severin ^{[1
]}

Alt, Eckhard ^{[1
]}

Khalek, F. J. Abdul ^{[1
]}

Jotzu, Constantin ^{[1
]}

Muehlberg, Fabian ^{[1
]}

Beckmann, Christoph ^{[1
]}

Song, Yao-Hua ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2009年 / 284卷 / 01期

关键词：

Breast cancer; Mesenchymal stem cell; Invasion; CCL5 (RANTES); Matrixmetalloproteinase; 9; ADIPOSE-TISSUE; STROMAL CELLS; EXPRESSION; MATRIX-METALLOPROTEINASE-9; RECEPTOR; INFLAMMATION; INVOLVEMENT; CCL5/RANTES; METASTASIS; CARCINOMA;

D O I：

10.1016/j.canlet.2009.04.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the present study, we investigated whether human adipose tissue derived stem cells (hASCs) could enhance tumor invasion and whether these hASCs could be a potential source of CCL5. We observed a significant increase in the number of breast cancer cells that invaded the matrigel when Co-cultured with hASCs. We found that hASCs produce CCL5 in the Co-culture and cancer cell invasion was diminished by an antibody against CCL5. Furthermore, cancer cell invasion in the Co-culture was associated with an elevated level of MMP-9 activity. We conclude that CCL5 plays a crucial role for tumor invasion in the interplay of tissue resident stem cells from the fat tissue and breast cancer cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：80 / 85

页数：6

共 21 条

[1] Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: Involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions [J].

Aldinucci, Donatella ;

Lorenzon, Debora ;

Cattaruzza, Lara ;

Pinto, Antonio ;

Gloghini, Annunziata ;

Carbone, Antonino ;

Colombatti, Alfonso .

INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (04) :769-776

[2] Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells [J].

Altman, Andrew M. ;

Matthias, Nadine ;

Yan, Yasheng ;

Song, Yao-Hua ;

Bai, Xiaowen ;

Chiu, Ernest S. ;

Slakey, Douglas P. ;

Alt, Eckhard U. .

BIOMATERIALS, 2008, 29 (10) :1431-1442

[3]

Azenshtein E, 2002, CANCER RES, V62, P1093

[4] VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells [J].

Bai, Xiaowen ;

Sadat, Sanga ;

Gehmert, Sebastian ;

Alt, Eckhard ;

Song, Yao-Hua .

FEBS LETTERS, 2007, 581 (24) :4681-4684

[5]

BAY, 2007, AM J PHYSIOL-CELL PH, pC1539

[6] CCL5-enhanced human immature dendritic cell migration through the basement membrane in vitro depends on matrix metalloproteinase-9 [J].

Chabot, Valerie ;

Reverdiau, Pascale ;

Iochmann, Sophie ;

Rico, Angelique ;

Senecal, Delphine ;

Goupille, Caroline ;

Sizaret, Pierre-Yves ;

Sensebe, Luc .

JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 79 (04) :767-778

[7] Inflammation and cancer [J].

Coussens, LM ;

Werb, Z .

NATURE, 2002, 420 (6917) :860-867

[8] Radial scars in benign breast-biopsy specimens and the risk of breast cancer [J].

Jacobs, TW ;

Byrne, C ;

Colditz, G ;

Connolly, JL ;

Schnitt, SJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (06) :430-436

[9] Mesenchymal stem cells within tumour stroma promote breast cancer metastasis [J].

Karnoub, Antoine E. ;

Dash, Ajeeta B. ;

Vo, Annie P. ;

Sullivan, Andrew ;

Brooks, Mary W. ;

Bell, George W. ;

Richardson, Andrea L. ;

Polyak, Kornelia ;

Tubo, Ross ;

Weinberg, Robert A. .

NATURE, 2007, 449 (7162) :557-U4

[10] Concise review: Adult multipotent stromal cells and cancer: Risk or benefit? [J].

Lazennec, Gwendal ;

Jorgensen, Christian .

STEM CELLS, 2008, 26 (06) :1387-1394

← 1 2 3 →