Preparative Separation of Chelerythrine and Sanguinarine from Macleaya cordata by pH-Zone-Refining Counter-current Chromatography
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作者:
Liu, Qian
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China
Shandong Agr Univ, Coll Food Sci & Engn, Tai An, Shandong, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China
Liu, Qian
[1
,2
]
Sun, Changlei
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China
Sun, Changlei
[1
]
Meng, Fansheng
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Shandong Univ, Jinan Cent Hosp, Jinan 250100, Shandong, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China
Meng, Fansheng
[3
]
Zhao, Wei
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China
Zhao, Wei
[1
]
Li, Dapeng
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Shandong Agr Univ, Coll Food Sci & Engn, Tai An, Shandong, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China
Li, Dapeng
[2
]
Wang, Xiao
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China
Shandong Agr Univ, Coll Food Sci & Engn, Tai An, Shandong, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China
Wang, Xiao
[1
,2
]
机构:
[1] Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China
[2] Shandong Agr Univ, Coll Food Sci & Engn, Tai An, Shandong, Peoples R China
[3] Shandong Univ, Jinan Cent Hosp, Jinan 250100, Shandong, Peoples R China
Chelerythrine and sanguinarine are the representative and major active constituents of Macleaya cordata. Few reports regarding the preparative separation of these two alkaloids from this Chinese herbal medicine were found. In the present study, an efficient method was established to separate chelerythrine and sanguinarine from Macleaya cordata by pH-zone-refining counter-current chromatography. The crude sample was separated into two fractions, which corresponded to chelerythrine (a) and sanguinarine (b) with the two-phase solvent system chloroform-ethyl acetate-methanol-water (3:1:3:2, v/v/v/v) where 10mM HCl was added in the upper phase and 10mM trithylamine in the lower phase. From 2.0g of crude extract, chelerythrine (600mg) and sanguinarine (750mg) were obtained in a single run with the purity of both over 95.0% as determined by HPLC. The chemical structures were confirmed by electrospray ionization-mass spectrometry, H-1 NMR and C-13 NMR.
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页码:1789 / 1793
页数:5
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
Fang, Lei
Liu, Yuqin
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
Liu, Yuqin
Yang, Bin
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China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
Yang, Bin
Wang, Xiao
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
Wang, Xiao
Huang, Luqi
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China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
Fang, Lei
Liu, Yuqin
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
Liu, Yuqin
Yang, Bin
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China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
Yang, Bin
Wang, Xiao
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Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China
Wang, Xiao
Huang, Luqi
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China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R ChinaShandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China