Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19)

被引：19

作者：

Scagnolari, Carolina ^{[1
]}

Pierangeli, Alessandra ^{[1
]}

Frasca, Federica ^{[1
]}

Bitossi, Camilla ^{[1
]}

Viscido, Agnese ^{[1
]}

Oliveto, Giuseppe ^{[1
]}

Scordio, Mirko ^{[1
]}

Mazzuti, Laura ^{[1
]}

Di Carlo, Daniele ^{[1
]}

Gentile, Massimo ^{[1
]}

Solimini, Angelo ^{[2
]}

Ceccarelli, Giancarlo ^{[2
]}

Pugliese, Francesco ^{[3
]}

Mastroianni, Claudio Maria ^{[2
]}

d'Ettorre, Gabriella ^{[2
]}

Turriziani, Ombretta ^{[1
]}

Antonelli, Guido ^{[1
,4
]}

机构：

[1] Sapienza Univ, Dept Mol Med, Lab Virol, Affiliated Ist Pasteur Italia, I-00185 Rome, Italy

[2] Sapienza Univ, Dept Publ Hlth & Infect Dis, Viale Policlin 155, I-00185 Rome, Italy

[3] Sapienza Univ, Dept Gen & Specialist Surg Paride Stefanini, Viale Policlin 155, I-00185 Rome, Italy

[4] Sapienza Univ, Hosp Policlin Umberto 1, Microbiol & Virol Unit, I-00185 Rome, Italy

来源：

VIRUS RESEARCH | 2021年 / 295卷

关键词：

COVID-19; IFN alpha; beta; ISG; Innate immunity; SARS-CoV-2; IFN lambda; RESPONSES; SARS;

D O I：

10.1016/j.virusres.2020.198283

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.

引用

页数：3

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