Microinversions in mammalian evolution

被引：29

作者：

Chaisson, M. J. ^{[1
]}

Raphael, B. J.

Pevzner, P. A.

机构：

[1] Univ Calif San Diego, Bioinformat Program, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Comp Sci & Engn, La Jolla, CA 92093 USA

[3] Brown Univ, Dept Comp Sci, Ctr Computat Mol Biol, Providence, RI 02906 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 52期

关键词：

genome rearrangements; phylogenetics;

D O I：

10.1073/pnas.0603984103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We propose an approach for identifying microinversions across different species and show that microinversions provide a source of low-homoplasy evolutionary characters. These characters may be used as "certificates" to verify different branches in a phylogenetic tree, turning the challenging problem of phylogeny reconstruction into a relatively simple algorithmic problem. We estimate that there exist hundreds of thousands of microinversions in genomes of mammals from comparative sequencing projects, an untapped source of new phylogenetic characters.

引用

页码：19824 / 19829

页数：6

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