Say NO to ET

被引：88
作者：
Vanhoutte, PM [1 ]
机构：
[1] Inst Rech Int Servier, F-92415 Courbevoie, France
来源：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 2000年 / 81卷 / 1-3期
关键词：
D O I：
10.1016/S0165-1838(00)00126-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The endothelial cells relase both relaxing [nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin] and contracting factors [endoperoxides, thromboxane A(2), superoxide anions, endothelin-1 (ET)]. The production of ET is inhibited by NO. The latter also strongly opposes the direct effects of the former on vascular smooth muscle. With aging and vascular disease, the production of enothelial NO declines, and thus ET can be released, act and contribute to the symptoms. (C) 2000 Elsevier Science B.V. All rights reserved.
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收藏
页码：271 / 277
页数：7
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