Serum DKK1 is correlated with γ peak of serum electrophoresis in multiple myeloma: a multicenter biomarker study

被引：3
|
作者：
Hashemi, Zahra Sadat [1 ]
Khalil, Saeed [2 ,3 ]
Malaei, Fatemeh [2 ]
Mard-Soltani, Maysam [4 ]
Jafarisani, Moslem [5 ]
Lotfi, Jabar [6 ]
Deemeh, Mohammad Reza [6 ]
Zakeri, Alireza [3 ]
Rasaee, Mohamad Javad [2 ]
机构：
[1] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran
[2] Tarbiat Modares Univ, Fac Med Sci, Dept Med Biotechnol, Tehran, Iran
[3] Shahid Rajaee Teacher Training Univ, Dept Biol Sci, Tehran, Iran
[4] Dezful Univ Med Sci, Fac Med Sci, Dept Clin Biochem, Dezful, Iran
[5] Shahroud Univ Med Sci, Canc Prevent Res Ctr, Clin Biochem, Shahroud, Iran
[6] Tarbiat Modares Univ, Fac Med Sci, Dept Clin Biochem, Tehran, Iran
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 15期
关键词：
Bence Jones proteins; bone disease; diagnosis; DKK1; ELISA; M protein; mesenchymal stem cells; multiple myeloma; serum protein electrophoresis; Wnt signaling; FREE LIGHT-CHAINS; MONOCLONAL GAMMOPATHY; BONE-DISEASE; CLINICAL-SIGNIFICANCE; DICKKOPF-1; PROTEINS; URINE; OSTEOBLASTS; INHIBITION; MECHANISM;
D O I：
10.2217/bmm-2019-0060
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: DKK1 is reported to be produced at high levels by myeloma cells. Therefore, the applicability of DKK1 as a tumor marker for multiple myeloma (MM) diagnosis was examined. Methods: Serum samples were collected and analyzed by DKK1 concentration kit and capillary zone electrophoresis. Then, the obtained results were statically analyzed. Results: It has been determined that the 10 ng/ml of DKK1 is the optimal level for MM diagnosis. Moreover, there was an ascending linear correlation between the DKK1 concentration and gamma peak. Discussion: The observed correlation could be rooted in the positive feedback loop between MM cells and the mesenchymal stem cells. In view of these results, DKK1 could be deemed as diagnostic marker for MM.
引用
收藏
页码：1297 / 1306
页数：10
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