Melanin-Associated Synthesis of SERS-Active Nanostructures and the Application for Monitoring of Intracellular Melanogenesis

被引：12

作者：

Dong, Haixin ^{[1
]}

Liu, Zhiming ^{[1
]}

Zhong, Huiqing ^{[1
]}

Yang, Hui ^{[2
]}

Zhou, Yan ^{[2
]}

Hou, Yuqing ^{[1
]}

Long, Jia ^{[2
]}

Lin, Jin ^{[2
]}

Guo, Zhouyi ^{[1
]}

机构：

[1] South China Normal Univ, Coll Biophoton, SATCM Grade Lab Chinese Med & Photon Technol 3, Guangzhou 510631, Guangdong, Peoples R China

[2] Infinitus China Co Ltd, Guangzhou 510665, Guangdong, Peoples R China

来源：

NANOMATERIALS | 2017年 / 7卷 / 03期

基金：

中国国家自然科学基金;

关键词：

surface-enhanced Raman scattering; melanin-Ag nanocomposites; bioimaging; melanogenesis; GREEN SYNTHESIS; SILVER NANOPARTICLES; GOLD NANOPARTICLES; MELANOSOMES; ANTIBACTERIAL; CELLS;

D O I：

10.3390/nano7030070

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Melanin plays an indispensable role in the human body. It serves as a biological reducer for the green synthesis of precious metal nanoparticles. Melanin-Ag nanocomposites were successfully produced which exhibited very strong surface-enhanced Raman scattering (SERS) effect because of the reducibility property of melanin. A melanin-Ag composite structure was synthesized in situ in melanin cells, and SERS technique was performed for the rapid imaging and quantitative assay of intracellular melanin. This imaging technique was also used to successfully trace the formation and secretion of intracellular melanin after stimulation with melanin-stimulating hormones. Based on the self-reducing property of melanin, the proposed SERS imaging method can provide potentially powerful analytical detection tools to study the biological functions of melanin and to prevent and cure melanin-related diseases.

引用

页数：9

共 31 条

[1] Raman Imaging in Biochemical and Biomedical Applications. Diagnosis and Treatment of Breast Cancer [J].