GM130 regulates epithelial-to-mesenchymal transition and invasion of gastric cancer cells via snail

被引:1
作者
Zhao, Jianquan [1 ]
Yang, Chun [2 ]
Guo, Shujun [1 ]
Wu, Yonggang [3 ]
机构
[1] Bayannaoer City Hosp, Dept Cardiol, Bayannaoer, Inner Mongolia, Peoples R China
[2] Bayannaoer City Hosp, Dept Med Cosmetol, Bayannaoer, Inner Mongolia, Peoples R China
[3] Bayannaoer City Hosp, Dept Orthoped, Bayannaoer, Inner Mongolia, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 09期
关键词
GM130; gastric cancer; EMT; invasion; migration; GOLGI MATRIX PROTEIN; MULTIDRUG-RESISTANCE; METASTASIS; INHIBITION; APOPTOSIS; DISEASE; GROWTH; GENE;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Gastric cancer is one of the most common causes of digestive tract tumor. Despite of recent advances in surgical techniques and development of adjuvant therapy, the underlying mechanisms of gastric cancer remain poorly understood and relevant insight into novel treatment strategies using gene target remains incomplete. Recently, several studies report that epithelial to mesenchymal transition (EMT) is a crucial process for the invasion and metastasis of epithelial tumors; however, the molecular mechanisms underlying this transition are unknown. As a cis-Golgi matrix protein, GM130 plays an important role in cell cycle progression and transport of protein in the secretory pathway. In this study, we found that GM130 expression has a positive correlation with the pathological differentiation and tumor node metastasis (TNM) stage of gastric cancer. High GM130 expression levels also predict shorter overall survival of gastric cancer patients. RNA interference-mediated knockdown of GM130 expression increased epithelial marker (E-cadherin) and decreased mesenchymal marker (N-cadherin and vimentin) expression in gastric cancer cells, suppressing cell invasion, and tumor formation. Furthermore, we found that GM130 upregulated expression of the key EMT regulator Snail (SNAI1), which mediated EMT activation and cell invasion by GM130. Taken together, our study indicates GM130 may be a promising therapeutic biomarker for gastric cancer.
引用
收藏
页码:10784 / 10791
页数:8
相关论文
共 50 条
[41]   miR-146a promotes proliferation, invasion, and epithelial-to-mesenchymal transition in oral squamous carcinoma cells [J].
Wang, Fan ;
Ye, Li-Jun ;
Wang, Feng-Juan ;
Liu, Hong-Fang ;
Wang, Xiao-Long .
ENVIRONMENTAL TOXICOLOGY, 2020, 35 (10) :1050-1057
[42]   XBP1 induces snail expression to promote epithelial- to-mesenchymal transition and invasion of breast cancer cells [J].
Li, Haiyu ;
Chen, Xingfeng ;
Gao, Yue ;
Wu, Jiayan ;
Zeng, Fan ;
Song, Fangzhou .
CELLULAR SIGNALLING, 2015, 27 (01) :82-89
[43]   Irisin suppresses the migration, proliferation, and invasion of lung cancer cells via inhibition of epithelial-to-mesenchymal transition [J].
Shao, Lei ;
Li, Huanjie ;
Chen, Jian ;
Song, Haibo ;
Zhang, Yuzhu ;
Wu, Fei ;
Wang, Wenjuan ;
Zhang, Wen ;
Wang, Fang ;
Li, Hui ;
Tang, Dongqi .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 485 (03) :598-605
[44]   Heparanase potentiates the invasion and migration of pancreatic cancer cells via epithelial-to-mesenchymal transition through the Wnt/β-catenin pathway [J].
Wang, Cheng ;
Wei, Yajun ;
Wang, Gang ;
Zhou, Yangming ;
Zhang, Jingcheng ;
Xu, Kai .
ONCOLOGY REPORTS, 2020, 44 (02) :711-721
[45]   Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer [J].
Sciacovelli, Marco ;
Frezza, Christian .
FEBS JOURNAL, 2017, 284 (19) :3132-3144
[46]   Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity [J].
Hong, Deli ;
Fritz, Andrew J. ;
Zaidi, Sayyed K. ;
van Wijnen, Andre J. ;
Nickerson, Jeffrey A. ;
Imbalzano, Anthony N. ;
Lian, Jane B. ;
Stein, Janet L. ;
Stein, Gary S. .
JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (12) :9136-9144
[47]   Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer [J].
Ding, Chenbo ;
Luo, Junmin ;
Li, Longmei ;
Li, Shanshan ;
Yang, Liwen ;
Pan, Hongfei ;
Liu, Qianyi ;
Qin, Huan ;
Chen, Chao ;
Feng, Jihong .
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 35
[48]   Small breast epithelial mucin promotes the invasion and metastasis of breast cancer cells via promoting epithelial-to-mesenchymal transition [J].
Li, Qiu-Hua ;
Liu, Zhao-Zhe ;
Ge, Ya-Nan ;
Liu, Xing ;
Xie, Xiao-Dong ;
Zheng, Zhen-Dong ;
Ma, Yue-Hai ;
Liu, Bin .
ONCOLOGY REPORTS, 2020, 44 (02) :509-518
[49]   β-III tubulin modulates the behavior of Snail overexpressed during the epithelial-to-mesenchymal transition in colon cancer cells [J].
Sobierajska, Katarzyna ;
Wieczorek, Katarzyna ;
Ciszewski, Wojciech M. ;
Sacewicz-Hofman, Izabela ;
Wawro, Marta E. ;
Wiktorska, Magdalena ;
Boncela, Joanna ;
Papiewska-Pajak, Izabela ;
Kwasniak, Pawel ;
Wyroba, Elzbieta ;
Cierniewski, Czeslaw S. ;
Niewiarowska, Jolanta .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2016, 1863 (09) :2221-2233
[50]   Regulation of miRNAs by Snail during epithelial-to-mesenchymal transition in HT29 colon cancer cells [J].
Przygodzka, Patrycja ;
Papiewska-Pajak, Izabela ;
Bogusz-Koziarska, Helena ;
Sochacka, Ewelina ;
Boncela, Joanna ;
Kowalska, M. Anna .
SCIENTIFIC REPORTS, 2019, 9 (1)