Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission

被引:115
作者
Bambico, Francis Rodriguez [1 ]
Nguyen, Nhu-Tram [1 ]
Katz, Noam [1 ]
Gobbi, Gabriella [1 ]
机构
[1] McGill Univ, Dept Psychiat, Neurobiol Psychiat Unit, Montreal, PQ H3A 1A1, Canada
关键词
Cannabinoids; Adolescence; Serotonin; Norepinephrine; Anxiety; Depression; ELEVATED PLUS-MAZE; RAT FRONTAL-CORTEX; 5-HT1A RECEPTOR ANTAGONIST; DORSAL RAPHE NUCLEUS; FORCED SWIM TEST; IN-VIVO; LOCUS-COERULEUS; FIRING ACTIVITY; ANIMAL-MODEL; CB1; RECEPTOR;
D O I
10.1016/j.nbd.2009.11.020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The pathophysiological neural mechanism underlying the depressogenic and anxiogenic effects of chronic adolescent cannabinoid use may be linked to perturbations in monoaminergic neurotransmission. We tested this hypothesis by administering the CB1 receptor agonist WIN55,212-2, once daily for 20 days to adolescent and adult rats, subsequently subjecting them to tests for emotional reactivity paralleled by the in vivo extracellular recordings of serotonergic and noradrenergic neurons. Chronic adolescent exposure but not adult exposure to low (0.2 mg/kg) and high (1.0 mg/kg) doses led to depression-like behaviour in the forced swim and sucrose preference test, while the high dose also induced anxiety-like consequences in the novelty-suppressed feeding test Electrophysiological recordings revealed both doses to have attenuated serotonergic activity, while the high dose also led to a hyperactivity of noradrenergic neurons only after adolescent exposure. These suggest that long-term exposure to cannabinoids during adolescence induces anxiety-like and depression-like behaviours in adulthood and that this may be instigated by serotonergic hypoactivity and noradrenergic hyperactivity. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:641 / 655
页数:15
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