Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation

被引：20

作者：

Bian, Minjuan ^{[1
,2
]}

Zhang, Yong ^{[3
]}

Du, Xiaoye ^{[1
,2
]}

Xu, Jing ^{[4
]}

Cui, Jingang ^{[1
,2
]}

Gu, Jiangping ^{[4
]}

Zhu, Weiliang ^{[3
]}

Zhang, Teng ^{[1
,2
]}

Chen, Yu ^{[1
,2
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Yueyang Hosp, Shanghai 200437, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Clin Res Inst Integrat Med, Shanghai 200437, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[4] East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

来源：

BRAIN RESEARCH | 2017年 / 1663卷

基金：

中国国家自然科学基金;

关键词：

Apigenin-7-diglucuronide; Photoreceptor degeneration; Oxidative stress; Retinal inflammation; APOPTOSIS IN-VITRO; MACULAR DEGENERATION; MICROGLIAL ACTIVATION; PERILLA-FRUTESCENS; CELLS; DAMAGE; CONSTITUENTS; HYDROETHIDINE; MECHANISMS; RPE;

D O I：

10.1016/j.brainres.2017.03.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vision impairment in retinal degenerative diseases such as age-related macular degeneration is primarily associated with photoreceptor degeneration, in which oxidative stress and inflammatory responses are mechanistically involved as central players. Therapies with photoreceptor protective properties remain to be developed. Apigenin-7-diglucuronide (A7DG), a flavonoid glycoside, is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. However, the pharmacological significance of A7DG remains unknown in vivo. The current study isolated A7DG from Glechoma longituba (Nakai) Kuprian and investigated the retinal protective effect A7DG in mice characterized by bright light-induced photoreceptor degeneration. The results showed that A7DG treatment led to remarkable photoreceptor protection in bright light-exposed BALB/c mice. Moreover, A7DG treatment alleviated photoreceptor apoptosis, mitigated oxidative stress, suppressed reactive gliosis and microglial activation and attenuated the expression of proinflammatory genes in bright light-exposed retinas. The results demonstrated for the first time remarkable photoreceptor protective activities of A7DG in vivo. Inhibition of bright light-induced retinal oxidative stress and retinal inflammatory responses was associated with the retinal protection conferred by A7DG. The work here warrants further evaluation of A7DG as a pharmacological candidate for the treatment of vision-threatening retinal degenerative disorders. Moreover, given the general implication of oxidative stress and inflammation in the pathogenesis of neurodegeneration, A7DG could be further tested for the treatment of other neurodegenerative disorders. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：141 / 150

页数：10