Search for Bioactive Natural Products Targeting Cancer-Related Signaling Pathways

被引：20
作者：
Ishibashi, Masami [1 ]
Arai, Midori A. [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan
来源：
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2009年 / 67卷 / 11期
基金：
日本科学技术振兴机构;
关键词：
MYXOMYCETE PHYSARUM-MELLEUM; SMALL-MOLECULE ANTAGONISTS; TRAIL-INDUCED APOPTOSIS; QUINIC ACID-ESTERS; CURCUMA-PARVIFLORA; DRUG DISCOVERY; UP-REGULATION; ABSOLUTE STEREOCHEMISTRY; MEDIATED TRANSCRIPTION; MILLETTIA-BRANDISIANA;
D O I：
10.5059/yukigoseikyokaishi.67.1094
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
During our studies related to the search for bioactive natural products, we recently examined extracts of various natural resources including unexplored myxomycetes, marine organisms, as well as several medicinal plants collected in the north-eastern part of Thailand and Bangladesh. Here we describe our recent results from our screening programs targeting signaling molecules in cancer-related biological pathways such as TRAIL, Writ, and Hedgehog signalings.
引用
收藏
页码：1094 / 1104
页数：11
相关论文
共 64 条
  • [1] Tyrosine Derivatives Isolated from Streptomyces sp IFM 10937 in a Screening Program for TRAIL-Resistance-Overcoming Activity
    Ahmed, Firoj
    Ohtsuki, Takashi
    Aida, Wataru
    Ishibashi, Masami
    [J]. JOURNAL OF NATURAL PRODUCTS, 2008, 71 (11): : 1963 - 1966
  • [2] First isolation of three diterpenes as naturally-occurring compounds from Sindora siamensis
    Aoki, Wataru
    Ohtsuki, Takashi
    Sadhu, Samir Kumar
    Sato, Masaaki
    Koyano, Takashi
    Preeprame, Srisomporn
    Kowithayakorn, Thaworn
    Ishibashi, Masami
    [J]. JOURNAL OF NATURAL MEDICINES, 2007, 61 (01) : 77 - 79
  • [3] ARAI MA, 1997, UNPUB
  • [4] Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana
    Arai, Midori A.
    Tateno, Chikashi
    Hosoya, Takahiro
    Koyano, Takashi
    Kowithayakorn, Thaworn
    Ishibashi, Masami
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (21) : 9420 - 9424
  • [5] Arai MA, 2008, HETEROCYCLES, V76, P1425
  • [6] Efficient Synthesis of Chromone and Flavonoid Derivatives with Diverse Heterocyclic Units
    Arai, Midori A.
    Sato, Mina
    Sawada, Keisuke
    Hosoya, Takahiro
    Ishibashi, Masami
    [J]. CHEMISTRY-AN ASIAN JOURNAL, 2008, 3 (12) : 2056 - 2064
  • [7] Mining the Wnt pathway for cancer therapeutics
    Barker, Nick
    Clevers, Hans
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (12) : 997 - 1014
  • [8] Natural products to drugs: natural product-derived compounds in clinical trials
    Butler, Mark S.
    [J]. NATURAL PRODUCT REPORTS, 2008, 25 (03) : 475 - 516
  • [9] Small molecule modulation of Smoothened activity
    Chen, JK
    Taipale, J
    Young, KE
    Maiti, T
    Beachy, PA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) : 14071 - 14076
  • [10] New antibiotics from bacterial natural products
    Clardy, Jon
    Fischbach, Michael A.
    Walsh, Christopher T.
    [J]. NATURE BIOTECHNOLOGY, 2006, 24 (12) : 1541 - 1550
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