TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

被引:0
|
作者
Healy, Shannon [1 ]
Ennishi, Daisuke [1 ]
Bashashati, Ali [1 ]
Saberi, Saeed [1 ]
Hother, Christoffer [1 ]
Mottok, Anja [1 ]
Chan, Fong Chun [2 ]
Chong, Lauren [1 ]
Kridel, Robert [3 ]
Boyle, Merrill [1 ]
Meissner, Barbara [1 ]
Aoki, Tomohiro [1 ]
Takata, Katsuyoshi [1 ]
Woolcock, Bruce W. [1 ]
Vigano, Elena [1 ]
Abraham, Libin [2 ]
Gold, Michael [2 ]
Telenius, Adele [1 ]
Farinha, Pedro [1 ]
Slack, Graham [1 ]
Ben-Neriah, Susana [1 ]
Lai, Daniel [1 ]
Zhang, Allen W. [1 ]
Salehi, Sohrab [1 ]
Shulha, Hennady P. [1 ]
Chiu, Derek S. [2 ]
Mostafavi, Sara [2 ]
Gerrie, Alina S. [1 ]
Villa, Diego [1 ]
Sehn, Laurie H. [1 ]
Savage, Kerry J. J. [1 ]
Mungall, Andrew J. J. [1 ]
Weng, Andrew P. [1 ]
Bally, Marcel [1 ]
Morin, Ryan D. [4 ]
Freue, Gabriela V. Cohen [2 ]
Connors, Joseph M. [1 ]
Marra, Marco A. [1 ]
Shah, Sohrab P. [1 ]
Gascoyne, Randy D. [1 ]
Scott, David W. [1 ]
Steidl, Christian [1 ]
Steidl, Ulrich [5 ]
机构
[1] BC Canc Agcy, Vancouver, BC, Canada
[2] Univ British Columbia, Vancouver, BC, Canada
[3] Univ Hlth Network, Toronto, ON, Canada
[4] Simon Fraser Univ, Vancouver, BC, Canada
[5] Albert Einstein Coll Med, Bronx, NY 10467 USA
关键词
D O I
10.1158/1538-7445.SABCS18-3480
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3480
引用
收藏
页数:10
相关论文
共 39 条
  • [31] Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells
    O'Hayre, M.
    Inoue, A.
    Kufareva, I.
    Wang, Z.
    Mikelis, C. M.
    Drummond, R. A.
    Avino, S.
    Finkel, K.
    Kalim, K. W.
    DiPasquale, G.
    Guo, F.
    Aoki, J.
    Zheng, Y.
    Lionakis, M. S.
    Molinolo, A. A.
    Gutkind, J. S.
    ONCOGENE, 2016, 35 (29) : 3771 - 3780
  • [32] Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma
    Y Xia
    Z Y Xu-Monette
    A Tzankov
    X Li
    G C Manyam
    V Murty
    G Bhagat
    S Zhang
    L Pasqualucci
    C Visco
    K Dybkaer
    A Chiu
    A Orazi
    Y Zu
    K L Richards
    E D Hsi
    W W L Choi
    J H van Krieken
    J Huh
    M Ponzoni
    A J M Ferreri
    M B Møller
    B M Parsons
    J N Winter
    M A Piris
    J Westin
    N Fowler
    R N Miranda
    C Y Ok
    Y Li
    J Li
    L J Medeiros
    K H Young
    Leukemia, 2017, 31 : 625 - 636
  • [33] Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma
    Xia, Y.
    Xu-Monette, Z. Y.
    Tzankov, A.
    Li, X.
    Manyam, G. C.
    Murty, V.
    Bhagat, G.
    Zhang, S.
    Pasqualucci, L.
    Visco, C.
    Dybkaer, K.
    Chiu, A.
    Orazi, A.
    Zu, Y.
    Richards, K. L.
    Hsi, E. D.
    Choi, W. W. L.
    van Krieken, J. H.
    Huh, J.
    Ponzoni, M.
    Ferreri, A. J. M.
    Moller, M. B.
    Parsons, B. M.
    Winter, J. N.
    Piris, M. A.
    Westin, J.
    Fowler, N.
    Miranda, R. N.
    Ok, C. Y.
    Li, Y.
    Li, J.
    Medeiros, L. J.
    Young, K. H.
    LEUKEMIA, 2017, 31 (03) : 625 - 636
  • [34] Loss-of-Function of MYO5B is the Main Cause of Microvillus Inclusion Disease: 15 Novel Mutations and a CaCo-2 RNAi Cell Model
    Ruemmele, Frank M.
    Mueller, Thomas
    Schiefermeier, Natalia
    Ebner, Hannes L.
    Lechner, Silvia
    Pfaller, Kristian
    Thoeni, Cornelia E.
    Goulet, Olivier
    Lacaille, Florence
    Schmitz, Jacques
    Colomb, Virginie
    Sauvat, Frederique
    Revillon, Yann
    Canioni, Danielle
    Brousse, Nicole
    de Saint-Basile, Genevieve
    Lefebvre, Juliette
    Heinz-Erian, Peter
    Enninger, Axel
    Utermann, Gerd
    Hess, Michael W.
    Janecke, Andreas R.
    Huber, Lukas A.
    HUMAN MUTATION, 2010, 31 (05) : 544 - 551
  • [35] Mutations in the HLA class II genes leading to loss of expression of HLA-DR and HLA-DQ in diffuse large B-cell lymphoma
    Jordanova, ES
    Philippo, K
    Giphart, MJ
    Schuuring, E
    Kluin, PM
    IMMUNOGENETICS, 2003, 55 (04) : 203 - 209
  • [36] Mutations in the HLA class II genes leading to loss of expression of HLA-DR and HLA-DQ in diffuse large B-cell lymphoma
    Ekaterina S. Jordanova
    Katja Philippo
    Marius J. Giphart
    Ed Schuuring
    Philip M. Kluin
    Immunogenetics, 2003, 55 : 203 - 209
  • [37] TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma
    Erazo, Tatiana
    Evans, Chiara M.
    Zakheim, Daniel
    Chu, Karen L.
    Refermat, Alice Yunsi
    Asgari, Zahra
    Yang, Xuejing
    Ferreira, Mariana Da Silva
    Mehta, Sanjoy
    Russo, Marco Vincenzo
    Knezevic, Andrea
    Zhang, Xi-Ping
    Chen, Zhengming
    Fennell, Myles
    Garippa, Ralph
    Seshan, Venkatraman
    de Stanchina, Elisa
    Barbash, Olena
    Batlevi, Connie Lee
    Leslie, Christina S.
    Melnick, Ari M.
    Younes, Anas
    Kharas, Michael G.
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [38] Impact of Loss-of-Function and Dominant-Negative IKZF1 Deletions on Outcome in BCR-ABL1 Negative Pediatric B-Cell Acute Lymphoblastic Leukemia
    Gupta, S.
    Bakhshi, S.
    Kamal, V.
    PEDIATRIC BLOOD & CANCER, 2018, 65 : S119 - S119
  • [39] Cytogenetic Analysis of CpG-Oligonucleotide DSP30 plus Interleukin-2-Stimulated Canine B-Cell Lymphoma Cells Reveals the Loss of One X Chromosome as the Sole Abnormality
    Reimann-Berg, N.
    Escobar, H. Murua
    Kiefer, Y.
    Mischke, R.
    Willenbrock, S.
    Eberle, N.
    Nolte, I.
    Bullerdiek, J.
    CYTOGENETIC AND GENOME RESEARCH, 2011, 135 (01) : 79 - 82