TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

被引：0

作者：

Healy, Shannon ^{[1
]}

Ennishi, Daisuke ^{[1
]}

Bashashati, Ali ^{[1
]}

Saberi, Saeed ^{[1
]}

Hother, Christoffer ^{[1
]}

Mottok, Anja ^{[1
]}

Chan, Fong Chun ^{[2
]}

Chong, Lauren ^{[1
]}

Kridel, Robert ^{[3
]}

Boyle, Merrill ^{[1
]}

Meissner, Barbara ^{[1
]}

Aoki, Tomohiro ^{[1
]}

Takata, Katsuyoshi ^{[1
]}

Woolcock, Bruce W. ^{[1
]}

Vigano, Elena ^{[1
]}

Abraham, Libin ^{[2
]}

Gold, Michael ^{[2
]}

Telenius, Adele ^{[1
]}

Farinha, Pedro ^{[1
]}

Slack, Graham ^{[1
]}

Ben-Neriah, Susana ^{[1
]}

Lai, Daniel ^{[1
]}

Zhang, Allen W. ^{[1
]}

Salehi, Sohrab ^{[1
]}

Shulha, Hennady P. ^{[1
]}

Chiu, Derek S. ^{[2
]}

Mostafavi, Sara ^{[2
]}

Gerrie, Alina S. ^{[1
]}

Villa, Diego ^{[1
]}

Sehn, Laurie H. ^{[1
]}

Savage, Kerry J. J. ^{[1
]}

Mungall, Andrew J. J. ^{[1
]}

Weng, Andrew P. ^{[1
]}

Bally, Marcel ^{[1
]}

Morin, Ryan D. ^{[4
]}

Freue, Gabriela V. Cohen ^{[2
]}

Connors, Joseph M. ^{[1
]}

Marra, Marco A. ^{[1
]}

Shah, Sohrab P. ^{[1
]}

Gascoyne, Randy D. ^{[1
]}

Scott, David W. ^{[1
]}

Steidl, Christian ^{[1
]}

Steidl, Ulrich ^{[5
]}

机构：

[1] BC Canc Agcy, Vancouver, BC, Canada

[2] Univ British Columbia, Vancouver, BC, Canada

[3] Univ Hlth Network, Toronto, ON, Canada

[4] Simon Fraser Univ, Vancouver, BC, Canada

[5] Albert Einstein Coll Med, Bronx, NY 10467 USA

来源：

CANCER RESEARCH | 2019年 / 79卷 / 13期

关键词：

D O I：

10.1158/1538-7445.SABCS18-3480

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

3480

引用

页数：10

共 39 条

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[23] Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma
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[25] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma.
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Suzuki, Ritsuro
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[26] MiR-30a increases MDSC differentiation and immunosuppressive function by targeting SOCS3 in mice with B-cell lymphoma
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[27] TP53 Mutations and RNA Binding Protein Musashi 2 Drive Resistance to PRMT5-Targeted Therapy in B-Cell Lymphoma
Erazo, Ingrid Tatiana
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[28] CIITA or RFX coding region loss of function mutations occur rarely in diffuse large B-cell lymphoma cases and cell lines with low levels of major histocompatibility complex class II expression
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[29] Generation of mouse models carrying B cell restricted single or multiplexed loss-of-function mutations through CRISPR-Cas9 gene editing
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[30] Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells
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