TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

被引：0

作者：

Healy, Shannon ^{[1
]}

Ennishi, Daisuke ^{[1
]}

Bashashati, Ali ^{[1
]}

Saberi, Saeed ^{[1
]}

Hother, Christoffer ^{[1
]}

Mottok, Anja ^{[1
]}

Chan, Fong Chun ^{[2
]}

Chong, Lauren ^{[1
]}

Kridel, Robert ^{[3
]}

Boyle, Merrill ^{[1
]}

Meissner, Barbara ^{[1
]}

Aoki, Tomohiro ^{[1
]}

Takata, Katsuyoshi ^{[1
]}

Woolcock, Bruce W. ^{[1
]}

Vigano, Elena ^{[1
]}

Abraham, Libin ^{[2
]}

Gold, Michael ^{[2
]}

Telenius, Adele ^{[1
]}

Farinha, Pedro ^{[1
]}

Slack, Graham ^{[1
]}

Ben-Neriah, Susana ^{[1
]}

Lai, Daniel ^{[1
]}

Zhang, Allen W. ^{[1
]}

Salehi, Sohrab ^{[1
]}

Shulha, Hennady P. ^{[1
]}

Chiu, Derek S. ^{[2
]}

Mostafavi, Sara ^{[2
]}

Gerrie, Alina S. ^{[1
]}

Villa, Diego ^{[1
]}

Sehn, Laurie H. ^{[1
]}

Savage, Kerry J. J. ^{[1
]}

Mungall, Andrew J. J. ^{[1
]}

Weng, Andrew P. ^{[1
]}

Bally, Marcel ^{[1
]}

Morin, Ryan D. ^{[4
]}

Freue, Gabriela V. Cohen ^{[2
]}

Connors, Joseph M. ^{[1
]}

Marra, Marco A. ^{[1
]}

Shah, Sohrab P. ^{[1
]}

Gascoyne, Randy D. ^{[1
]}

Scott, David W. ^{[1
]}

Steidl, Christian ^{[1
]}

Steidl, Ulrich ^{[5
]}

机构：

[1] BC Canc Agcy, Vancouver, BC, Canada

[2] Univ British Columbia, Vancouver, BC, Canada

[3] Univ Hlth Network, Toronto, ON, Canada

[4] Simon Fraser Univ, Vancouver, BC, Canada

[5] Albert Einstein Coll Med, Bronx, NY 10467 USA

来源：

CANCER RESEARCH | 2019年 / 79卷 / 13期

关键词：

D O I：

10.1158/1538-7445.SABCS18-3480

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

3480

引用

页数：10

共 39 条

[1] TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma
Ennishi, Daisuke
Healy, Shannon
Bashashati, Ali
Saberi, Saeed
Hother, Christoffer
Mottok, Anja
Chan, Fong Chun
Chong, Lauren
Abraham, Libin
Kridel, Robert
Boyle, Merrill
Meissner, Barbara
Aoki, Tomohiro
Takata, Katsuyoshi
Woolcock, Bruce W.
Vigano, Elena
Gold, Michael
Molday, Laurie L.
Molday, Robert S.
Telenius, Adele
Li, Michael Y.
Wretham, Nicole
Dos Santos, Nancy
Wong, Mark
Viller, Natasja N.
Uger, Robert A.
Duns, Gerben
Baticados, Abigail
Madero, Angel
Bristow, Brianna N.
Farinha, Pedro
Slack, Graham W.
Ben-Neriah, Susana
Lai, Daniel
Zhang, Allen W.
Salehi, Sohrab
Shulha, Hennady P.
Chiu, Derek S.
Mostafavi, Sara
Gerrie, Alina S.
Huang, Da Wei
Rushton, Christopher
Villa, Diego
Sehn, Laurie H.
Savage, Kerry J.
Mungall, Andrew J.
Weng, Andrew P.
Bally, Marcel B.
Morin, Ryan D.
Cohen Freue, Gabriela V.
NATURE MEDICINE, 2020, 26 (04) : 577 - +
[2] TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma
Daisuke Ennishi
Shannon Healy
Ali Bashashati
Saeed Saberi
Christoffer Hother
Anja Mottok
Fong Chun Chan
Lauren Chong
Libin Abraham
Robert Kridel
Merrill Boyle
Barbara Meissner
Tomohiro Aoki
Katsuyoshi Takata
Bruce W. Woolcock
Elena Viganò
Michael Gold
Laurie L. Molday
Robert S. Molday
Adele Telenius
Michael Y. Li
Nicole Wretham
Nancy Dos Santos
Mark Wong
Natasja N. Viller
Robert A. Uger
Gerben Duns
Abigail Baticados
Angel Madero
Brianna N. Bristow
Pedro Farinha
Graham W. Slack
Susana Ben-Neriah
Daniel Lai
Allen W. Zhang
Sohrab Salehi
Hennady P. Shulha
Derek S. Chiu
Sara Mostafavi
Alina S. Gerrie
Da Wei Huang
Christopher Rushton
Diego Villa
Laurie H. Sehn
Kerry J. Savage
Andrew J. Mungall
Andrew P. Weng
Marcel B. Bally
Ryan D. Morin
Gabriela V. Cohen Freue
Nature Medicine, 2020, 26 : 577 - 588
[3] TET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma
Asmar, F.
Christensen, J.
Punj, V
Pedersen, Terndrup M.
Pedersen, A.
Nielsen, Blabjerg A.
Hother, C.
Ralfkiaer, U.
Ralfkiaer, E.
Helin, K.
Gronbaek, K.
APMIS, 2012, 120 : 36 - 37
[4] TET2 LOSS-OF-FUNCTION MUTATIONS ASSOCIATE WITH A DNA HYPERMETHYLATION SIGNATURE IN DIFFUSE LARGE B-CELL LYMPHOMA
Asmar, F.
Christensen, J.
Punj, V.
Pedersen, M.
Pedersen, A.
Nielsen, A.
Hother, C.
Ralfkiaer, U.
Brown, P.
Ralfkiaer, E.
Helin, K.
Gronbaek, K.
HAEMATOLOGICA, 2012, 97 : 246 - 246
[5] Loss-of-function lesions impact B-cell development and fitness but are insufficient to drive CLL in mouse models
ten Hacken, Elisa
Yin, Shanye
Redd, Robert
Sanchez, Maria Hernandez
Clement, Kendell
Hoffmann, Gabriela Brunsting
Regis, Fara F.
Witten, Elizabeth
Li, Shuqiang
Neuberg, Donna
Pinello, Luca
Livak, Kenneth J.
Wu, Catherine J.
BLOOD ADVANCES, 2023, 7 (16) : 4514 - 4517
[6] Mutations of the B-Cell Receptor Pathway Confer Chemoresistance in Primary Cutaneous Diffuse Large B-Cell Lymphoma Leg Type
Ducharme, Oceane
Beylot-Barry, Marie
Pham-Ledard, Anne
Bohers, Elodie
Viailly, Pierre-Julien
Bandres, Thomas
Faur, Nicolas
Frison, Eric
Vergier, Beatrice
Jardin, Fabrice
Merlio, Jean-Philippe
Gros, Audrey
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (11) : 2334 - +
[7] Loss-of-Function Missense Mutations in Tyrosine Phosphatase PTPN6 Deregulate STAT3 Signaling in Diffuse Large B-Cell Lymphoma
Demosthenous, Christos
Hu, Guangzhen
Witzig, Thomas E.
Gupta, Mamta
BLOOD, 2014, 124 (21)
[8] Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development
Mito, Takayuki
Kikkawa, Yoshiaki
Shimizu, Akinori
Hashizume, Osamu
Katada, Shun
Imanishi, Hirotake
Ota, Azusa
Kato, Yukina
Nakada, Kazuto
Hayashi, Jun-Ichi
PLOS ONE, 2013, 8 (02):
[9] B-cell Function Gene Mutations in Diffuse Large B-cell Lymphoma: A Retrospective Cohort Study
Xu, Peng-Peng
Zhong, Hui-Juan
Huang, Yao-Hui
Gao, Xiao-Dong
Zhao, Xia
Shen, Yang
Cheng, Shu
Huang, Jin-Yan
Chen, Sai-Juan
Wang, Li
Zhao, Wei-Li
EBIOMEDICINE, 2017, 16 : 106 - 114
[10] Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma
Markus Schick
Le Zhang
Sabine Maurer
Hans Carlo Maurer
Konstandina Isaakaidis
Lara Schneider
Upayan Patra
Kathrin Schunck
Elena Rohleder
Julia Hofstetter
Apoorva Baluapuri
Anna Katharina Scherger
Julia Slotta-Huspenina
Franziska Hettler
Julia Weber
Thomas Engleitner
Roman Maresch
Jolanta Slawska
Richard Lewis
Rouzanna Istvanffy
Stefan Habringer
Katja Steiger
Armin Baiker
Robert A. J. Oostendorp
Cornelius Miething
Hans-Peter Lenhof
Florian Bassermann
Björn Chapuy
Matthias Wirth
Elmar Wolf
Roland Rad
Stefan Müller
Ulrich Keller
Nature Communications, 13

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