Obesity increases the incidence of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in an ovariectomized Zucker rat model

被引:0
|
作者
Hakkak, Reza
MacLeod, Stewart
Shaaf, Saeid
Holley, Andy W.
Simpson, Pippa
Fuchs, George
Jo, Chan Hee
Kieber-Emmons, Thomas
Korourian, Soheila
机构
[1] Univ Arkansas Med Sci, Dept Nutr & Dietet, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA
[3] Arkansas Childrens Hosp, Inst Res, Little Rock, AR 72202 USA
[4] Univ Arkansas Med Sci, Arkansas Canc Res Ctr, Little Rock, AR 72205 USA
[5] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA
关键词
obesity; Zucker rats; DMBA-induced mammary tumors;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Obesity is associated with increased risk for postmenopausal, but not premenopausal breast cancer. Recently, we reported that intact obese Zucker rats had increased susceptibility to DMBA-induced mammary tumors compared to lean Zucker rats. In the present study, we investigated whether excessive adipose tissue would promote mammary tumor induction in the absence of ovarian estrogen. Lean and obese rats were sham-operated or ovariectomized at 40 days old and were gavaged at 50 days old with 65 mg/kg DMBA. Rats were weighed and palpated twice weekly for detection of mammary tumors and sacrificed 135 days post-DMBA treatment. Obese sham-operated (O/S) rats had a shorter latency period (102 days) compared to lean sham-operated (L/S) (134 days) and obese ovariectomized (O/O) rats (123 days). At the end of the experiment, 36% of the O/O rats developed mammary tumors while lean ovariectomized (L/O) rats developed no mammary tumors (P < 0.001), and 59% of the O/S rats developed mammary tumors compared to 30% of the L/S rats (P < 0.05). In summary, obesity increases the susceptibility of ovariectomized Zucker rats to DMBA-induced mammary tumors, suggesting that adipose tissue-derived estrogen in obese animals may be sufficient to promote DMBA-induced tumors in this model. These results suggest that obesity in postmenopausal women may increase breast cancer risk due to increased breast tissue exposure to adipose tissue-derived estrogen. In conclusion, we have developed an animal model to further investigate the role of obesity in breast cancer development in postmenopausal women.
引用
收藏
页码:557 / 563
页数:7
相关论文
共 50 条
  • [31] ANTIESTROGEN-BINDING SITES IN 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED RAT MAMMARY-TUMORS - RELATION TO GROWTH
    HWANG, PLH
    HOW, BE
    ONCOLOGY, 1990, 47 (06) : 495 - 500
  • [32] INHIBITION OF 7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED MAMMARY-TUMORS AND DNA ADDUCTS BY GARLIC POWDER
    LIU, JZ
    LIN, RI
    MILNER, JA
    CARCINOGENESIS, 1992, 13 (10) : 1847 - 1851
  • [33] PROLACTIN BINDING TO 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED MAMMARY-TUMORS AND LIVER IN DIABETIC RATS
    SMITH, RD
    HILF, R
    SENIOR, AE
    CANCER RESEARCH, 1977, 37 (11) : 4070 - 4074
  • [34] PROLACTIN RECEPTORS IN 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED MAMMARY-TUMORS FOLLOWING ENDOCRINE ABLATION
    COSTLOW, ME
    BUSCHOW, RA
    MCGUIRE, WL
    CANCER RESEARCH, 1976, 36 (11) : 3941 - 3943
  • [35] INHIBITION OF 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED MAMMARY-TUMORS AND DNA ADDUCTS BY DIETARY SELENITE
    LIU, JZ
    GILBERT, K
    PARKER, HM
    HASCHEK, WM
    MILNER, JA
    CANCER RESEARCH, 1991, 51 (17) : 4613 - 4617
  • [36] Commercial soy milk enhances the development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats
    Qin, Li-Qiang
    Xu, Jia-Ying
    Tezuka, Hideo
    Wang, Pei-Yu
    Hoshi, Kazuhiko
    IN VIVO, 2007, 21 (04): : 667 - 671
  • [37] ESTROGEN-PROLACTIN DEPENDENCY IN 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED TUMORS
    LEUNG, BS
    SASAKI, GH
    LEUNG, JS
    CANCER RESEARCH, 1975, 35 (03) : 621 - 627
  • [38] Possible enhancing effects of atrazine on growth of 7,12-dimethylbenz(a) anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats
    Ueda, M
    Imai, T
    Takizawa, T
    Onodera, H
    Mitsumori, K
    Matsui, T
    Hirose, M
    CANCER SCIENCE, 2005, 96 (01): : 19 - 25
  • [39] MODIFICATION OF THE EFFECT OF A GONADOLIBERIN ANALOG ON 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED RAT MAMMARY-TUMORS BY HORMONE REPLACEMENT
    ROSE, DP
    PRUITT, B
    CANCER RESEARCH, 1979, 39 (10) : 3968 - 3970
  • [40] 7,12-Dimethylbenz[a]anthracene-Induced Malignancies in a Mouse Model of Menopause
    Marion, Samuel L.
    Watson, Jennifer
    Sen, Nivedita
    Brewer, Molly A.
    Barton, Jennifer K.
    Hoyer, Patricia B.
    COMPARATIVE MEDICINE, 2013, 63 (01) : 6 - 12