Amination of Alcohols Catalyzed by Copper-Aluminium Hydrotalcite: A Green Synthesis of Amines

被引：123
|
作者：
Likhar, Pravin R. [1 ]
Arundhathi, Racha [1 ]
Kantam, Mannepalli Lakshmi [1 ]
Prathima, Parvathaneni Sai [1 ]
机构：
[1] Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500670, Andhra Pradesh, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 31期
关键词：
Heterogeneous catalysis; Hydrotalcite; Amines; Amination; Alcohols; Anilines; CHAIN TERMINAL ALCOHOLS; N-ALKYLATION; SECONDARY-AMINES; TERTIARY-AMINES; HETEROAROMATIC AMINES; HYDROAMINATION; AMINOARENES; CONVERSION; HETEROCYCLIZATION; ARYLATION;
D O I：
10.1002/ejoc.200900628
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-aluminium hydrotalcite (CuAl-HT)/K2CO3 has been employed in the activation of various benzyl alcohols with benzylamines to afford the corresponding amines in good to high yields. Experimentation showed that the reaction takes place through sequential transformations: the oxidation of alcohols into carbonyl compounds, imine formation between amines and carbonyl compounds, and then reduction of imines to amines, heterogeneously catalyzed by non-noble Cu-Al HT catalyst in a one-pot and straightforward fashion. The process was further extended to amination of alcohols with anilines, which are often resistant to alkylation reactions when substituted with strong electron-withdrawing groups. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
引用
收藏
页码：5383 / 5389
页数：7
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