Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice

被引：8
|
作者：
Niwa, Kenji
Lian, Zenglin
Onogi, Kyoko
Yun, Wu
Tang, Liulin
Mori, Hideki
Tamaya, Teruhiko
机构：
[1] Gifu Univ, Sch Med, Dept Obstet & Gynecol, Gifu 5011194, Japan
[2] Gifu Univ, Sch Med, Dept Tumor Pathol, Gifu 5011194, Japan
来源：
ONCOLOGY REPORTS | 2007年 / 17卷 / 03期
关键词：
glycyrrhizin; Glycyrrhizae radix; chemoprevention; endometrial carcinogenesis; COX-2;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have previously reported on the inhibitory effect of Glycyrrhizae radix (Gl radix) on mouse endometrial carcinogenesis. The present study was performed to clarify the effects of Gl radix and glycyrrhizin (GL), the main part of Gl radix, on estradiol (E-2)-related endometrial carcinogenesis. Both Gl radix and GL exerted a significant decrease in the COX-2, IL-1 alpha and TNF-alpha mRNA expressions. GL generated a significant decrease in the incidence of endometrial adenocarcinoma. Accordingly, the preventive effects of G1 radix may be attributable to GL, thus being related with the suppression of COX-2, IL-1 alpha and TNF-alpha Gl radix and GL could therefore be a promising formula for the chemoprevention of human endometrial cancer.
引用
收藏
页码：617 / 622
页数：6
相关论文
共 50 条
  • [1] Preventive effects of Glycyrrhizae radix extract on estrogen-related endometrial carcinogenesis in mice
    Niwa, K
    Hashimoto, M
    Morishita, S
    Yokoyama, Y
    Mori, H
    Tamaya, T
    JAPANESE JOURNAL OF CANCER RESEARCH, 1999, 90 (07): : 726 - 732
  • [2] Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells
    Mori, H
    Niwa, K
    Zheng, Q
    Yamada, Y
    Sakata, K
    Yoshimi, N
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2001, 480 : 201 - 207
  • [3] Preventive effects of danazol on endometrial carcinogenesis in mice
    Niwa, K
    Hashimoto, M
    Morishita, S
    Yokoyama, Y
    Lian, ZL
    Tagami, K
    Mori, H
    Tamaya, T
    CANCER LETTERS, 2000, 158 (02) : 133 - 139
  • [4] Preventive effects of isoflavones, genistein and daidzein, on estradiol-17β-related endometrial carcinogenesis in mice
    Lian, ZL
    Niwa, K
    Tagami, K
    Hashimoto, M
    Gao, JC
    Yokoyama, Y
    Mori, H
    Tamaya, T
    JAPANESE JOURNAL OF CANCER RESEARCH, 2001, 92 (07): : 726 - 734
  • [5] COMUTAGENICITY OF ESTROGENS AS A POSSIBLE MECHANISM IN ESTROGEN-RELATED CARCINOGENESIS
    PURDY, RH
    MARSHALL, MV
    BREAST CANCER RESEARCH AND TREATMENT, 1984, 4 (04) : 353 - 353
  • [6] Function of estrogen-related receptor α in human endometrial cancer
    Watanabe, A
    Kinoshita, Y
    Hosokawa, K
    Mori, T
    Yamaguchi, T
    Honjo, H
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (04): : 1573 - 1577
  • [7] Estrogen-related receptor α as a potential molecular target for endometrial cancer therapy
    Kokabu, T.
    Mori, T.
    Matsushima, H.
    Tarumi, Y.
    Yoriki, K.
    Kuroboshi, H.
    Sawada, M.
    Umemura, S.
    Kitawaki, J.
    ANNALS OF ONCOLOGY, 2018, 29
  • [8] Reliable estrogen-related prognostic signature for uterine corpus endometrial carcinoma
    Li, Mojuan
    Wang, Shuai
    Huang, Hao
    Li, Li
    COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2024, 113
  • [9] Effects of tamoxifen on endometrial carcinogenesis in mice
    Niwa, K
    Morishita, S
    Hashimoto, M
    Itoh, T
    Fujimoto, J
    Mori, H
    Tamaya, T
    JAPANESE JOURNAL OF CANCER RESEARCH, 1998, 89 (05): : 502 - 509
  • [10] Dual targeting of estrogen receptor α and estrogen-related receptor α: a novel endocrine therapy for endometrial cancer
    Mao, XiaoDan
    Dong, Binhua
    Gao, Min
    Ruan, GuanYu
    Huang, MeiMei
    Braicu, Elena Loana
    Sehouli, Jalid
    Sun, PengMing
    ONCOTARGETS AND THERAPY, 2019, 12 : 6757 - 6767
12345