Aldehyde Dehydrogenase Inhibitors for Cancer Therapeutics

被引：72

作者：

Dinavahi, Saketh S. ^{[1
,5
]}

Bazewicz, Christopher G. ^{[3
,5
]}

Gowda, Raghavendra ^{[1
,5
,6
,7
]}

Robertson, Gavin P. ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Penn State Univ, Coll Med, Dept Pharmacol, Hershey, PA 17033 USA

[2] Penn State Univ, Coll Med, Dept Pathol, Hershey, PA 17033 USA

[3] Penn State Univ, Coll Med, Dept Dermatol, Hershey, PA 17033 USA

[4] Penn State Univ, Coll Med, Dept Surg, Hershey, PA 17033 USA

[5] Penn State Univ, Coll Med, Penn State Melanoma & Skin Canc Ctr, Hershey, PA 17033 USA

[6] Penn State Univ, Coll Med, Penn State Melanoma Therapeut Program, Hershey, PA 17033 USA

[7] Penn State Univ, Coll Med, Foreman Fdn Melanoma Res, Hershey, PA 17033 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2019年 / 40卷 / 10期

关键词：

STEM-CELL MARKER; SELECTIVE INHIBITORS; INITIATING CELLS; EXPRESSION; ALDH1; RESISTANCE; MECHANISM; TARGET; 1A1; ACTIVATION;

D O I：

10.1016/j.tips.2019.08.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aldehyde dehydrogenases (ALDHs) are highly expressed in the chemotherapy- and radiotherapy-resistant cell subpopulations of many different cancer types. Accordingly, the development of ALDH inhibitors may be the most direct approach to target these cell populations. However, inhibiting multiple ALDH family members can be toxic and isoform-specific inhibition is often ineffective. This review discusses the role of ALDH in cancer and therapy resistance, and then overviews the various available ALDH inhibitors with a focus on the clinical potential ant limitations of these agents as cancer therapeutics. Finally, challenges and future research direrctions to effectively target ALDH in the management of cancer therapy resistance are discussed.

引用

页码：774 / 789

页数：16

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