Dendrimers: Emerging polymers for drug-delivery systems

被引：371
作者：
Nanjwade, Basavaraj K. [1 ]
Bechra, Hiren M. [1 ]
Derkar, Ganesh K. [1 ]
Manvi, F. V. [1 ]
Nanjwade, Veerendra K. [2 ]
机构：
[1] KLE Univ, JN Med Coll, Dept Pharmaceut, Belgaum 590010, India
[2] KLE Univ, KLE Coll Pharm, Dept Pharmaceut, Bangalore 560010, Karnataka, India
来源：
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2009年 / 38卷 / 03期
关键词：
Dendrimer; Dendrimer synthesis; Dendrimer properties; Dendrimer types; Dendrimer applications; PAMAM; IN-VITRO; CONTRAST AGENTS; POLYAMIDOAMINE DENDRIMERS; DENDRITIC MACROMOLECULES; TRANSDERMAL DELIVERY; PAMAM DENDRIMERS; BUILDING-BLOCKS; CHEMISTRY; MOLECULES; CARRIERS;
D O I：
10.1016/j.ejps.2009.07.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dendrimers are new class of polymeric materials. It is generally described as a macromolecule, which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. The unique properties associated with these dendrimers such as uniform size, high degree of branching, water solubility, multivalency,well-defined molecular weight and available internal cavities make them attractive for biological and drug-delivery applications. Commercialization of dendrimers is now forthcoming. The present review briefly describes about dendrimer synthesis strategies, types of dendrimers with different functionalities, properties which having crucial importance and their potential applications. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：185 / 196
页数：12
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