New Therapeutics for Ulcerative Colitis

被引：117

作者：

Hirten, Robert P. ^{[1
]}

Sands, Bruce E. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dr Henry D Janowitz Div Gastroenterol, New York, NY 10029 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 72, 2021 | 2021年 / 72卷

关键词：

ulcerative colitis; Crohn's disease; janus kinase inhibitor; sphingosine receptor modulator; anti-adhesion therapy; anti-interleukin inhibitor; inflammatory bowel disease; FECAL MICROBIOTA TRANSPLANTATION; JANUS KINASE INHIBITOR; SEVERE CROHNS-DISEASE; CONTROLLED-TRIAL; COMBINATION THERAPY; MAINTENANCE THERAPY; PHASE-III; PSORIATIC-ARTHRITIS; INDUCTION THERAPY; DOUBLE-BLIND;

D O I：

10.1146/annurev-med-052919-120048

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Ulcerative colitis (UC) is a relapsing and remitting inflammatory disease of the colon with a variable course. Despite advances in treatment, only approximately 40% of patients achieve clinical remission at the end of a year, prompting the exploration of new treatment modalities. This review explores novel therapeutic approaches to UC, including promising drugs in various stages of development, efforts to maximize the efficacy of currently available treatment options, and non-medication-based modalities. Treatment approaches which show promise in impacting the future of UC management are highlighted.

引用

页码：199 / 213

页数：15

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