PTEN function in mammalian cell size regulation

被引：78
作者：
Backman, SA
Stambolic, V
Mak, TW
机构：
[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada
[2] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 05期
关键词：
D O I：
10.1016/S0959-4388(02)00354-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3'kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.
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收藏
页码：516 / 522
页数：7
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