Ars2 and the Cap-Binding Complex Team up for Silencing

被引:11
作者
Nielsen, Anne F. [1 ]
Gloggnitzer, Jiradet [1 ]
Martinez, Javier [1 ]
机构
[1] Austrian Acad Sci, Inst Mol Biotechnol, A-1030 Vienna, Austria
基金
奥地利科学基金会;
关键词
SMALL RNAS; ARABIDOPSIS; SERRATE;
D O I
10.1016/j.cell.2009.07.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this issue, Sabin et al. (2009) and Gruber et al. (2009) reveal the protein Ars2 as a versatile regulator of RNA silencing. They show that Ars2 stimulates microRNA processing, contributes to antiviral resistance in flies, and is important for cell proliferation in mammals.
引用
收藏
页码:224 / 226
页数:4
相关论文
共 8 条
  • [1] Origins and Mechanisms of miRNAs and siRNAs
    Carthew, Richard W.
    Sontheimer, Erik J.
    [J]. CELL, 2009, 136 (04) : 642 - 655
  • [2] Antiviral immunity directed by small RNAs
    Ding, Shou-Wei
    Voinnet, Olivier
    [J]. CELL, 2007, 130 (03) : 413 - 426
  • [3] The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1
    Dong, Zhicheng
    Han, Meng-Hsuan
    Fedoroff, Nina
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (29) : 9970 - 9975
  • [4] SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis
    Grigg, SP
    Canales, C
    Hay, A
    Tsiantis, M
    [J]. NATURE, 2005, 437 (7061) : 1022 - 1026
  • [5] Biogenesis of small RNAs in animals
    Kim, V. Narry
    Han, Jinju
    Siomi, Mikiko C.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (02) : 126 - 139
  • [6] Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana
    Laubinger, Sascha
    Sachsenberg, Tirno
    Zeller, Georg
    Busch, Wolfgang
    Lohmann, Jan U.
    Raescht, Gunnar
    Weigel, Detlef
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (25) : 8795 - 8800
  • [7] Primary microRNA transcripts are processed co-transcriptionally
    Morlando, Mariangela
    Ballarino, Monica
    Gromak, Natalia
    Pagano, Francesca
    Bozzoni, Irene
    Proudfoot, Nick J.
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (09) : 902 - 909
  • [8] ARS2 is a conserved eukaryotic gene essential for early mammalian development
    Wilson, Michael D.
    Wang, Diana
    Wagner, Rebecca
    Breyssens, Hilde
    Gertsenstein, Marina
    Lobe, Corrinne
    Lu, Xin
    Nagy, Andras
    Burke, Robert D.
    Koop, Ben F.
    Howard, Perry L.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (05) : 1503 - 1514