Fluorescent characterization off peroxynitrite-induced thiyl radicals

被引：0

作者：

Dang, YM ^{[1
]}

Guo, XQ ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem, Key Lab Analyt Sci MOE, Xiamen 361005, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2006年 / 27卷 / 03期

关键词：

spin-labeling; fluorescent probe; thiyl radical; peroxynitrite;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A spin-labeling fluorophore (Ac-Tempo(.)), formed by combining with an acridine with a paramagnetic nitroxide (4-hydroxyl-2, 2, 6, 6-tetramethylpiperidinyl-1-oxy), was explored for peptide-based thiyl radicals generated through the reaction between gluththione and peroxynitrite. Ac-Tempo(.), a weak fluorescent compound, showed a dramatic increase in fluorescence intensity after interaction with thiyl radicals, and could be employed to probe peptide-based thiyl radicals.

引用

页码：424 / 427

页数：4

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