Carotid Intima-Media Thickness Progression and Risk of Vascular Events in People With Diabetes: Results From the PROG-IMT Collaboration

被引：72

作者：

Lorenz, Matthias W. ^{[1
]}

Price, Jackie F. ^{[2
]}

Robertson, Christine ^{[2
]}

Bots, Michiel L. ^{[3
]}

Polak, Joseph F. ^{[4
]}

Poppert, Holger ^{[5
]}

Kavousi, Maryam ^{[6
]}

Doerr, Marcus ^{[7
]}

Stensland, Eva ^{[8
]}

Ducimetiere, Pierre ^{[9
]}

Ronkainen, Kimmo ^{[10
]}

Kiechl, Stefan ^{[11
]}

Sitzer, Matthias ^{[1
,12
]}

Rundek, Tatjana ^{[13
]}

Lind, Lars ^{[14
]}

Liu, Jing ^{[15
]}

Bergstrom, Goran ^{[16
]}

Grigore, Liliana ^{[17
,18
]}

Bokemark, Lena ^{[16
]}

Friera, Alfonsa ^{[19
]}

Yanez, David ^{[20
]}

Bickel, Horst ^{[21
]}

Ikram, M. Arfan ^{[6
]}

Voelzke, Henry ^{[22
,23
]}

Johnsen, Stein Harald ^{[8
,24
]}

Empana, Jean Philippe ^{[25
]}

Tuomainen, Tomi-Pekka ^{[10
]}

Willeit, Peter ^{[11
,26
]}

Steinmetz, Helmuth ^{[1
]}

Desvarieux, Moise ^{[27
,28
,29
]}

Xie, Wuxiang ^{[15
]}

Schmidt, Caroline ^{[16
]}

Norata, Giuseppe D. ^{[17
,30
]}

Suarez, Carmen ^{[31
]}

Sander, Dirk ^{[5
,32
]}

Hofman, Albert ^{[6
,33
]}

Schminke, Ulf ^{[34
]}

Mathiesen, Ellisiv ^{[8
,24
]}

Plichart, Matthieu ^{[25
,35
]}

Kauhanen, Jussi ^{[10
]}

Willeit, Johann ^{[11
]}

Sacco, Ralph L. ^{[13
]}

McLachlan, Stela ^{[2
]}

Zhao, Dong ^{[15
]}

Fagerberg, Bjorn ^{[16
]}

Catapano, Alberico L. ^{[18
,30
]}

Gabriel, Rafael ^{[36
]}

Franco, Oscar H. ^{[6
]}

Buelbuel, Alpaslan ^{[1
]}

Scheckenbach, Frank ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Neurol, D-60054 Frankfurt, Germany

[2] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland

[3] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[4] Tufts Univ, Sch Med, Tufts Med Ctr, Boston, MA 02111 USA

[5] Tech Univ Munich, Univ Hosp, Dept Neurol, D-80290 Munich, Germany

[6] Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[7] Greifswald Univ Clin, Dept Internal Med Cardiol B, Greifswald, Germany

[8] Univ Tromso, Dept Clin Med, Tromso, Norway

[9] Univ Paris 11, Paris, France

[10] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland

[11] Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria

[12] Klinikum Herford, Dept Neurol, Herford, Germany

[13] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA

[14] Uppsala Univ, Dept Med, Uppsala, Sweden

[15] Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing, Peoples R China

[16] Univ Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden

[17] Bassini Hosp, SISA Ctr Study Atherosclerosis, Cinisello Balsamo, Italy

[18] IRCCS MultiMed, Milan, Italy

[19] Univ Autonoma Madrid, Hosp Univ la Princesa, Dept Radiol, Madrid, Spain

[20] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[21] Tech Univ Munich, Univ Hosp, Dept Psychiat, D-80290 Munich, Germany

[22] Univ Greifswald, SHIP Clin Epidemiol Res, Inst Community Med, Greifswald, Germany

[23] German Ctr Cardiovasc Res, Greifswald, Germany

[24] Univ Hosp Northern Norway, Dept Neurol & Neurophysiol, Tromso, Norway

[25] INSERM U970, Paris, France

[26] Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England

[27] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[28] Ecole Hautes Etud Sante Publ, Paris, France

[29] INSERM U738, Paris, France

[30] Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy

[31] Univ Autonoma Madrid, Hosp Univ la Princesa, Dept Internal Med, Madrid, Spain

[32] Benedictus Hosp Tutzing & Feldafing, Dept Neurol, Feldafing, Germany

[33] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[34] Greifswald Univ Clin, Dept Neurol, Greifswald, Germany

[35] Broca Hosp, Gerontol Dept, Paris, France

[36] Univ Autonoma Madrid, Hosp Univ La Paz, Inst Invest IdiPAZ, Madrid, Spain

[37] Inst Publ Hlth, MRC, Biostat Unit, Cambridge, England

来源：

DIABETES CARE | 2015年 / 38卷 / 10期

关键词：

IMPAIRED GLUCOSE-TOLERANCE; NONFATAL MYOCARDIAL-INFARCTION; CORONARY-HEART-DISEASE; ARTERY INTIMA; CARDIOVASCULAR EVENTS; SUBCLINICAL ATHEROSCLEROSIS; META-REGRESSION; METAANALYSIS; INDIVIDUALS; POPULATION;

D O I：

10.2337/dc14-2732

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVECarotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the association of CIMT change in repeated examinations with subsequent CVD events is uncertain, and its use as a surrogate end point in clinical trials is controversial. We aimed at determining the relation of CIMT change to CVD events in people with diabetes.RESEARCH DESIGN AND METHODSIn a comprehensive meta-analysis of individual participant data, we collated data from 3,902 adults (age 33-92 years) with type 2 diabetes from 21 population-based cohorts. We calculated the hazard ratio (HR) per standard deviation (SD) difference in mean common carotid artery intima-media thickness (CCA-IMT) or in CCA-IMT progression, both calculated from two examinations on average 3.6 years apart, for each cohort, and combined the estimates with random-effects meta-analysis.RESULTSAverage mean CCA-IMT ranged from 0.72 to 0.97 mm across cohorts in people with diabetes. The HR of CVD events was 1.22 (95% CI 1.12-1.33) per SD difference in mean CCA-IMT, after adjustment for age, sex, and cardiometabolic risk factors. Average mean CCA-IMT progression in people with diabetes ranged between -0.09 and 0.04 mm/year. The HR per SD difference in mean CCA-IMT progression was 0.99 (0.91-1.08).CONCLUSIONSDespite reproducing the association between CIMT level and vascular risk in subjects with diabetes, we did not find an association between CIMT change and vascular risk. These results do not support the use of CIMT progression as a surrogate end point in clinical trials in people with diabetes.

引用

页码：1921 / 1929

页数：9

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