Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

被引：31

作者：

Waller, Zoe A. E. ^{[1
]}

Pinchbeck, Benjamin J. ^{[2
]}

Buguth, Bhovina Seewoodharry ^{[1
]}

Meadows, Timothy G. ^{[1
]}

Richardson, David J. ^{[2
]}

Gates, Andrew J. ^{[2
]}

机构：

[1] Univ East Anglia, Sch Pharm, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England

[2] Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 92期

基金：

英国生物技术与生命科学研究理事会;

关键词：

SMALL-MOLECULE; C-MYC; TRANSCRIPTION; POLYMORPHISM; EXPRESSION; PARACOCCUS; PROMOTER; GENOME; CANCER; CELLS;

D O I：

10.1039/c6cc06057a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we present a chemical-biology study in themodel soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription.

引用

页码：13511 / 13514

页数：4

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