This article describes the structural design, nonlinear modeling, and seismic analysis of prototype single-storey non-residential steel buildings made of moment-resisting portal frames in the transverse direction and concentric braces in the longitudinal direction. Various design parameters (building geometry, seismic hazard, foundation soil category) and different modeling assumptions (bare frame model, model including cladding elements, ground motions including vertical accelerations, and modeling uncertainties) were considered to investigate their effects on the simulated seismic performance.