Canine distemper virus strains circulating among North American dogs

被引：42

作者：

Kapil, Sanjay ^{[1
,2
]}

Allison, Robin W. ^{[2
]}

Johnston, Larry, III

Murray, Brandy L.

Holland, Steven

Meinkoth, Jim ^{[2
]}

Johnson, Bill ^{[2
]}

机构：

[1] Ctr Vet Hlth Sci, OADDL, Stillwater, OK 74078 USA

[2] Ctr Vet Hlth Sci, Dept Vet Pathobiol, Stillwater, OK 74078 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2008年 / 15卷 / 04期

关键词：

D O I：

10.1128/CVI.00005-08

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Canine distemper virus (CDV) is a highly contagious virus that causes multisystemic disease in dogs. We received seven samples from dogs with CD from the United States during 2007. CDV isolates from these samples formed large, multinucleated syncytia in a Vero cell line expressing canine signaling lymphocyte activation molecule (SLAM). Based on the hemagglutinin gene sequences, the CDV isolates from three states (California, Missouri, and Oklahoma) formed two CDV genetic groups: group I (major; six of seven isolates) consisted of CDV isolates closely related to the European wildlife lineage of CDV, and group II (minor; one of seven isolates) was genetically related to the Arctic-like lineage of CDV. However, both CDV groups were genetically different from the current vaccine strains that belong to the American-1 lineage of the old (1930 to 1950) CDV isolates.

引用

页码：707 / 712

页数：6

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