Cavernoma-related epilepsy: Review and recommendations for management - Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies

被引：152

作者：

Rosenow, Felix ^{[1
]}

Alonso-Vanegas, Mario A. ^{[2
]}

Baumgartner, Christoph ^{[3
]}

Bluemcke, Ingmar ^{[4
]}

Carreno, Maria ^{[5
]}

Gizewski, Elke R. ^{[6
]}

Hamer, Hajo M. ^{[7
]}

Knake, Susanne ^{[1
]}

Kahane, Philippe ^{[8
,9
]}

Lueders, Hans O. ^{[10
]}

Mathern, Gary W. ^{[11
,12
]}

Menzler, Katja ^{[1
]}

Miller, Jonathan ^{[13
]}

Otsuki, Taisuke ^{[14
]}

Ozkara, Cigdem ^{[15
]}

Pitkaenen, Asla ^{[16
,17
]}

Roper, Steven N. ^{[18
]}

Sakamoto, Americo C. ^{[19
]}

Sure, Ulrich ^{[20
]}

Walker, Matthew C. ^{[21
,22
]}

Steinhoff, Bernhard J. ^{[23
]}

机构：

[1] Univ Hosp & Philipps Univ Marburg, Dept Neurol, Epilepsy Ctr Hessen, D-35043 Marburg, Germany

[2] ABC Neurol Ctr & Natl Inst Neurol & Neurosurg, Mexico City, DF, Mexico

[3] Gen Hosp Hietzing Neurol Ctr Rosenhugel, Karl Landsteiner Inst Clin Epilepsy Res & Cognit, Neurol Dept 2, Vienna, Austria

[4] Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Neuropathol, D-91054 Erlangen, Germany

[5] Hosp Clin Barcelona, Neurol Serv, Epilepsy Unit, Barcelona, Spain

[6] Med Univ Innsbruck, Dept Radiol, Univ Clin Neuroradiol, A-6020 Innsbruck, Austria

[7] Univ Erlangen Nurnberg, Dept Neurol, Epilepsy Ctr Erlangen, Univ Hosp Erlangen, D-91054 Erlangen, Germany

[8] Univ Hosp Grenoble, Dept Neurol, Grenoble, France

[9] Univ Hosp Grenoble, GIN INSERM UJF CEA U836, Grenoble, France

[10] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Epilepsy Ctr, Dept Neurosurg, Cleveland, OH 44106 USA

[11] Univ Calif Los Angeles, David Geffen Sch Med, Mattel Childrens Hosp, Dept Neurosurg, Los Angeles, CA 90095 USA

[12] Univ Calif Los Angeles, David Geffen Sch Med, Mattel Childrens Hosp, Dept Psychiat & BioBehav Med, Los Angeles, CA 90095 USA

[13] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Neurosurg, Cleveland, OH 44106 USA

[14] Natl Ctr Neurol & Psychiat, Epilepsy Ctr, Tokyo, Japan

[15] Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey

[16] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland

[17] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland

[18] Univ Florida, Dept Neurosurg, Gainesville, FL USA

[19] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Neurosci & Behav Sci, Sao Paulo, Brazil

[20] Univ Duisburg Essen, Univ Hosp Essen, Dept Neurosurg, Essen, Germany

[21] UCL Inst Neurol, Dept Clin & Expt Epilepsy, London, England

[22] Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England

[23] Kork Epilepsy Ctr, Kehl, Germany

来源：

EPILEPSIA | 2013年 / 54卷 / 12期

关键词：

Cavernous hemangioma; Epilepsy surgery; Etiology; Risk factors; Outcome; CEREBRAL ARTERIOVENOUS-MALFORMATIONS; SEIZURES PREOPERATIVE COURSE; OF-THE-LITERATURE; NATURAL-HISTORY; VASCULAR MALFORMATIONS; CONSECUTIVE PATIENTS; CLINICAL ARTICLE; SPINAL-CORD; ANGIOMAS; BRAIN;

D O I：

10.1111/epi.12402

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral cavernous malformations (CCMs) are well-defined, mostly singular lesions present in 0.4-0.9% of the population. Epileptic seizures are the most frequent symptom in patients with CCMs and have a great impact on social function and quality of life. However, patients with CCM-related epilepsy (CRE) who undergo surgical resection achieve postoperative seizure freedom in only about 75% of cases. This is frequently because insufficient efforts are made to adequately define and resect the epileptogenic zone. The Surgical Task Force of the Commission on Therapeutics of the International League Against Epilepsy (ILAE) and invited experts reviewed the pertinent literature on CRE. Definitions of definitive and probable CRE are suggested, and recommendations regarding the diagnostic evaluation and etiology-specific management of patients with CRE are made. Prospective trials are needed to determine when and how surgery should be done and to define the relations of the hemosiderin rim to the epileptogenic zone.

引用

页码：2025 / 2035

页数：11

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